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Directed cytoskeleton self-organization

Vignaud, Timothée ; Blanchoin, Laurent ; Théry, Manuel

Trends in cell biology, 2012-12, Vol.22 (12), p.671-682 [Periódico revisado por pares]

England: Elsevier Ltd

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Título:
Directed cytoskeleton self-organization
Autor: Vignaud, Timothée ; Blanchoin, Laurent ; Théry, Manuel
Assuntos: actin ; Actin Cytoskeleton - metabolism ; Actins - metabolism ; architecture ; Cell Membrane - metabolism ; Cell Polarity ; Cellular Biology ; Centrosome - metabolism ; Life Sciences ; microfabrication ; micropatterning ; microtubule ; Microtubules - metabolism ; Mitosis ; Molecular Motor Proteins - metabolism ; Pathology ; polarity ; Protein Conformation ; Protein Transport ; Spindle Apparatus - metabolism
É parte de: Trends in cell biology, 2012-12, Vol.22 (12), p.671-682
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: The cytoskeleton architecture supports many cellular functions. Cytoskeleton networks form complex intracellular structures that vary during the cell cycle and between different cell types according to their physiological role. These structures do not emerge spontaneously. They result from the interplay between intrinsic self-organization properties and the conditions imposed by spatial boundaries. Along these boundaries, cytoskeleton filaments are anchored, repulsed, aligned, or reoriented. Such local effects can propagate alterations throughout the network and guide cytoskeleton assembly over relatively large distances. The experimental manipulation of spatial boundaries using microfabrication methods has revealed the underlying physical processes directing cytoskeleton self-organization. Here we review, step-by-step, from molecules to tissues, how the rules that govern assembly have been identified. We describe how complementary approaches, all based on controlling geometric conditions, from in vitro reconstruction to in vivo observation, shed new light on these fundamental organizing principles.
Editor: England: Elsevier Ltd
Idioma: Inglês

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Directed cytoskeleton self-organization

Vignaud, Timothée ; Blanchoin, Laurent ; Théry, Manuel

England: Elsevier Ltd

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