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Influence of Single-Nucleotide Polymorphisms on C-Reactive Protein Levels in Chronic Kidney Disease Before and After Kidney Transplantation

Cordeiro, A.C ; de Castro, I ; Pecoits-Filho, R ; Ramasawmy, R ; Rodrigues, H ; Borba, S.C.P ; Pereira, L.M ; Romão, J.E ; David-Neto, E ; Ianhez, L.E ; Kalil, J ; Abensur, H

Transplantation proceedings, 2008-12, Vol.40 (10), p.3349-3353 [Periódico revisado por pares]

Amsterdam: Elsevier Inc

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Título:
Influence of Single-Nucleotide Polymorphisms on C-Reactive Protein Levels in Chronic Kidney Disease Before and After Kidney Transplantation
Autor: Cordeiro, A.C ; de Castro, I ; Pecoits-Filho, R ; Ramasawmy, R ; Rodrigues, H ; Borba, S.C.P ; Pereira, L.M ; Romão, J.E ; David-Neto, E ; Ianhez, L.E ; Kalil, J ; Abensur, H
Assuntos: Adult ; Biological and medical sciences ; C-Reactive Protein - genetics ; C-Reactive Protein - metabolism ; Cadaver ; DNA Primers ; Female ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Genetic Variation ; Genotype ; Humans ; Kidney Failure, Chronic - blood ; Kidney Failure, Chronic - surgery ; Kidney Transplantation - physiology ; Kidneys ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the urinary system ; Tissue Donors ; Tissue, organ and graft immunology ; Urinary system involvement in other diseases. Miscellaneous
É parte de: Transplantation proceedings, 2008-12, Vol.40 (10), p.3349-3353
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Abstract Introduction We sought to evaluate 2 single-nucleotide polymorphisms (SNPs) in the C-reactive protein (CRP) gene promoter region for their effects on CRP levels in chronic kidney disease (CKD) patients before and after a successful kidney transplantation. Methods Fifty CKD patients were evaluated before and at the first and second years after the graft. Two SNPs were studied, a bi-allelic (G→A) at the −409 and a tri-allelic (C→T→A) variation at the −390 position in the CRP gene. Results All patients presented the −409GG genotype. At the −390 position, the “A” allele was not found; there were 15 “CC” patients, 11 “TT” patients, and 24 “CT” patients. CRP levels were different among patients with various genotypes ( P < .019). Also the presence of the allele “T” was sufficient to determine differences in CRP levels both in pretransplantation ( P = .045) and at 1 year posttransplantation ( P = .011), but not at the second year ( P = .448). Conclusion SNPs at the −390 position of the CRP gene promoter region influence CRP basal levels in such a way that the “C” allele correlated with the lowest and the “T” with the highest. We did not observe this influence in our patients at the second year posttransplantation.
Editor: Amsterdam: Elsevier Inc
Idioma: Inglês

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Influence of Single-Nucleotide Polymorphisms on C-Reactive Protein Levels in Chronic Kidney Disease Before and After Kidney Transplantation

Cordeiro, A.C ; de Castro, I ; Pecoits-Filho, R ; Ramasawmy, R ; Rodrigues, H ; Borba, S.C.P ; Pereira, L.M ; Romão, J.E ; David-Neto, E ; Ianhez, L.E ; Kalil, J ; Abensur, H

Amsterdam: Elsevier Inc

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