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Effect of standard‐dose and high‐dose pimobendan on select indices of renal and cardiac function in dogs with American College of Veterinary Internal Medicine stage B2 myxomatous mitral valve disease

Kaplan, Joanna L. ; Visser, Lance C. ; Gunther‐Harrington, Catherine T. ; Ontiveros, Eric S. ; Wittenburg, Luke A. ; Palm, Carrie A. ; Stern, Joshua A.

Journal of veterinary internal medicine, 2022-11, Vol.36 (6), p.1892-1899 [Periódico revisado por pares]

Hoboken, USA: John Wiley & Sons, Inc

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  • Título:
    Effect of standard‐dose and high‐dose pimobendan on select indices of renal and cardiac function in dogs with American College of Veterinary Internal Medicine stage B2 myxomatous mitral valve disease
  • Autor: Kaplan, Joanna L. ; Visser, Lance C. ; Gunther‐Harrington, Catherine T. ; Ontiveros, Eric S. ; Wittenburg, Luke A. ; Palm, Carrie A. ; Stern, Joshua A.
  • Assuntos: azotemia ; Blood pressure ; canine ; Cardiac function ; Cardiovascular disease ; Contrast media ; Creatinine ; degenerative ; Density ; Dogs ; Dosage and administration ; Drug dosages ; Electrolytes ; Ethylenediaminetetraacetic acid ; Heart ; Heart failure ; Heart valve diseases ; High-definition television ; Hypertension ; Internal medicine ; kidney function ; Laboratories ; Lithium ; Natriuretic peptides ; Peptides ; Phlebotomy ; Plasma ; Quality of life ; subclinical ; Urine ; Veterinary medicine
  • É parte de: Journal of veterinary internal medicine, 2022-11, Vol.36 (6), p.1892-1899
  • Notas: Funding information
    American College of Veterinary Internal Medicine; Center for Companion Animal Health, UC Davis; NIH K award, Grant/Award Number: 5K01OD026526
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  • Descrição: Background Pimobendan might have favorable effects on renal function but this has not been well‐studied in dogs with myxomatous mitral valve disease (MMVD). Objectives Determine the effects of standard‐dose (SD_pimo) and high‐dose pimobendan (HD_pimo) on glomerular filtration rate (GFR) and cardiac size and function in dogs with preclinical MMVD. Animals Thirty nonazotemic dogs with stage B2 MMVD. Methods Prospective, randomized, double‐blinded, placebo‐controlled clinical study. Dogs had an echocardiographic examination, assessment of GFR (iohexol clearance), N‐terminal probrain natriuretic peptide (NT‐proBNP), and quality of life (QOL) score at baseline and 7 to 10 days after placebo (n = 6), SD_pimo 0.2 to 0.3 mg/kg q12 (n = 12), or HD_pimo 0.5 to 0.6 mg/kg q12h (n = 12). Results No significant differences in GFR or QOL scores were detected between groups (P ≥.07). After HD_pimo, the mean [SD] percent change of NT_proBNP (−46.1 [20.2]%), left atrial volume (LAV; −27.1 [16.9]%), left ventricular end‐diastolic volume (EDV; −21.8 [15.0]%), and end‐systolic volume (ESV; −55.0 [20.7]%) were significantly different (P ≤.004) from placebo (0.5 [19.9]%, 1.3 [15.6]%, −0.2 [8.2]%, −7.3 [35.6]%, respectively) but not the percent change after SD_pimo (−36.6 [16.1]%, −22.7 [14.9]%, −16.7 [12.5]%, −41.6 [14.8]%, respectively; P > .05). After SD_pimo, percent change of NT_proBNP, LAV, EDV, and ESV were significantly different from placebo (P < .05). Conclusions and Clinical Importance Results suggest that pimobendan (SD_pimo or HD_pimo) might not affect renal function in nonazotemic dogs with stage B2 MMVD. High‐dose pimobendan did not demonstrate advantages over SD_pimo within the constraints of our study.
  • Editor: Hoboken, USA: John Wiley & Sons, Inc
  • Idioma: Inglês
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