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Activation of CD8 + T Cells in Chronic Obstructive Pulmonary Disease Lung

Villaseñor-Altamirano, Ana B ; Jain, Dhawal ; Jeong, Yunju ; Menon, Jaivardhan A ; Kamiya, Mari ; Haider, Hibah ; Manandhar, Reshmi ; Sheikh, Muhammad Dawood Amir ; Athar, Humra ; Merriam, Louis T ; Ryu, Min Hyung ; Sasaki, Takanori ; Castaldi, Peter J ; Rao, Deepak A ; Sholl, Lynette M ; Vivero, Marina ; Hersh, Craig P ; Zhou, Xiaobo ; Veerkamp, Justus ; Yun, Jeong H ; Kim, Edy Y

American journal of respiratory and critical care medicine, 2023-12, Vol.208 (11), p.1177-1195 [Periódico revisado por pares]

United States: American Thoracic Society

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Título:
Activation of CD8 + T Cells in Chronic Obstructive Pulmonary Disease Lung
Autor: Villaseñor-Altamirano, Ana B ; Jain, Dhawal ; Jeong, Yunju ; Menon, Jaivardhan A ; Kamiya, Mari ; Haider, Hibah ; Manandhar, Reshmi ; Sheikh, Muhammad Dawood Amir ; Athar, Humra ; Merriam, Louis T ; Ryu, Min Hyung ; Sasaki, Takanori ; Castaldi, Peter J ; Rao, Deepak A ; Sholl, Lynette M ; Vivero, Marina ; Hersh, Craig P ; Zhou, Xiaobo ; Veerkamp, Justus ; Yun, Jeong H ; Kim, Edy Y
Assuntos: Animals ; CD8-Positive T-Lymphocytes ; Cells ; Chronic obstructive pulmonary disease ; Disease Models, Animal ; Humans ; Inflammation ; Lung - metabolism ; Mice ; Proteomics ; Pulmonary Disease, Chronic Obstructive ; Pulmonary fibrosis ; Receptors, Antigen, T-Cell
É parte de: American journal of respiratory and critical care medicine, 2023-12, Vol.208 (11), p.1177-1195
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Despite the importance of inflammation in chronic obstructive pulmonary disease (COPD), the immune cell landscape in the lung tissue of patients with mild-moderate disease has not been well characterized at the single-cell and molecular level. To define the immune cell landscape in lung tissue from patients with mild-moderate COPD at single-cell resolution. We performed single-cell transcriptomic, proteomic, and T-cell receptor repertoire analyses on lung tissue from patients with mild-moderate COPD ( = 5, Global Initiative for Chronic Obstructive Lung Disease I or II), emphysema without airflow obstruction ( = 5), end-stage COPD ( = 2), control ( = 6), or donors ( = 4). We validated in an independent patient cohort ( = 929) and integrated with the murine model of COPD. Mild-moderate COPD lungs have increased abundance of two CD8 T cell subpopulations: cytotoxic KLRG1 TIGIT CX3CR1 TEMRA (T effector memory CD45RA ) cells, and DNAM-1 CCR5 T resident memory (T ) cells. These CD8 T cells interact with myeloid and alveolar type II cells via and have hyperexpanded T-cell receptor clonotypes. In an independent cohort, the CD8 KLRG1 TEMRA cells are increased in mild-moderate COPD lung compared with control or end-stage COPD lung. Human CD8 KLRG1 TEMRA cells are similar to CD8 T cells driving inflammation in an aging-related murine model of COPD. CD8 TEMRA cells are increased in mild-moderate COPD lung and may contribute to inflammation that precedes severe disease. Further study of these CD8 T cells may have therapeutic implications for preventing severe COPD.
Editor: United States: American Thoracic Society
Idioma: Inglês

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Activation of CD8 + T Cells in Chronic Obstructive Pulmonary Disease Lung

United States: American Thoracic Society

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