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Patterned Piezoelectric Scaffolds for Osteogenic Differentiation

Marques-Almeida, Teresa ; Cardoso, Vanessa F ; Gama, Miguel ; Lanceros-Mendez, Senentxu ; Ribeiro, Clarisse

International journal of molecular sciences, 2020-11, Vol.21 (21), p.8352 [Periódico revisado por pares]

Switzerland: MDPI

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Título:
Patterned Piezoelectric Scaffolds for Osteogenic Differentiation
Autor: Marques-Almeida, Teresa ; Cardoso, Vanessa F ; Gama, Miguel ; Lanceros-Mendez, Senentxu ; Ribeiro, Clarisse
Assuntos: 3T3 Cells ; Animals ; Biocompatible Materials - chemistry ; Bone and Bones - metabolism ; Bone Regeneration - drug effects ; bone tissue engineering ; Cell Culture Techniques - methods ; cell differentiation ; Cell Differentiation - drug effects ; Cell Proliferation ; Cell Survival ; electroactive ; Hydrocarbons, Fluorinated - chemistry ; Hydrocarbons, Fluorinated - pharmacology ; Mice ; Osteoblasts - metabolism ; Osteogenesis ; patterning ; piezoelectric ; Polyvinyls - chemistry ; Tissue Engineering - methods ; Tissue Scaffolds - chemistry ; Titanium - chemistry ; Vinyl Compounds - chemistry ; Vinyl Compounds - pharmacology
É parte de: International journal of molecular sciences, 2020-11, Vol.21 (21), p.8352
Descrição: The morphological clues of scaffolds can determine cell behavior and, therefore, the patterning of electroactive polymers can be a suitable strategy for bone tissue engineering. In this way, this work reports on the influence of poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)) electroactive micropatterned scaffolds on the proliferation and differentiation of bone cells. For that, micropatterned P(VDF-TrFE) scaffolds were produced by lithography in the form of arrays of lines and hexagons and then tested for cell proliferation and differentiation of pre-osteoblast cell line. Results show that more anisotropic surface microstructures promote bone differentiation without the need of further biochemical stimulation. Thus, the combination of specific patterns with the inherent electroactivity of materials provides a promising platform for bone regeneration.
Editor: Switzerland: MDPI
Idioma: Inglês

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Patterned Piezoelectric Scaffolds for Osteogenic Differentiation

Marques-Almeida, Teresa ; Cardoso, Vanessa F ; Gama, Miguel ; Lanceros-Mendez, Senentxu ; Ribeiro, Clarisse

Switzerland: MDPI

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