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Physiological and pathological effects of amyloid-β species in neural stem cell biology

中国神经再生研究（英文版）, 2019, Vol.14 (12), p.2035-2042 [Periódico revisado por pares]

Unidad de Regeneración Neural, Unidad Funcional de Investigación de Enfermedades Crónicas. Instituto de Salud Carlos III (ISCIII), Majadahonda, Madrid, Spain

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  • Título:
    Physiological and pathological effects of amyloid-β species in neural stem cell biology
  • É parte de: 中国神经再生研究（英文版）, 2019, Vol.14 (12), p.2035-2042
  • Descrição: Although amyloid-β peptide is considered neurotoxic, it may mediate several physiological processes during embryonic development and in the adult brain. The pathological function of amyloid-β peptide has been ex-tensively studied due to its implication in Alzheimer’s disease, but its physiological function remains poorly understood. Amyloid-β peptide can be detected in non-aggregated (monomeric) and aggregated (oligomeric and fibrillary) forms. Each form has different cytotoxic and/or physiological properties, so amyloid-β pep-tide and its role in Alzheimer’s disease need to be studied further. Neural stem cells and neural precursor cells are good tools for the study on neurodegenerative diseases and can provide future therapeutic applica-tions in diseases such as Alzheimer’s disease. In this review, we provide an outline of the effects of amyloid-β peptide, in monomeric and aggregated forms, on the biology of neural stem cells/neural precursor cells, and discuss the controversies. We also describe the possib
  • Editor: Unidad de Regeneración Neural, Unidad Funcional de Investigación de Enfermedades Crónicas. Instituto de Salud Carlos III (ISCIII), Majadahonda, Madrid, Spain
  • Idioma: Chinês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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