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Circulating miR-122-5p/miR-133b Ratio Is a Specific Early Prognostic Biomarker in Acute Myocardial Infarction

Cortez-Dias, Nuno ; Costa, Marina C. ; Carrilho-Ferreira, Pedro ; Silva, Doroteia ; Jorge, Cláudia ; Calisto, Carina ; Pessoa, Teresa ; Martins, Susana Robalo ; Sousa, João Carvalho de ; Silva, Pedro Canas da ; Fiúza, Manuela ; Diogo, António Nunes ; Pinto, Fausto J. ; Enguita, Francisco J.

Circulation Journal, 2016/09/23, Vol.80(10), pp.2183-2191 [Periódico revisado por pares]

Japan: The Japanese Circulation Society

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Título:
Circulating miR-122-5p/miR-133b Ratio Is a Specific Early Prognostic Biomarker in Acute Myocardial Infarction
Autor: Cortez-Dias, Nuno ; Costa, Marina C. ; Carrilho-Ferreira, Pedro ; Silva, Doroteia ; Jorge, Cláudia ; Calisto, Carina ; Pessoa, Teresa ; Martins, Susana Robalo ; Sousa, João Carvalho de ; Silva, Pedro Canas da ; Fiúza, Manuela ; Diogo, António Nunes ; Pinto, Fausto J. ; Enguita, Francisco J.
Assuntos: Aged ; Biomarkers - blood ; Circulating miRNAs ; Female ; Humans ; Male ; MicroRNAs - blood ; Middle Aged ; miR-122-5p ; miR-133b ; Myocardial infarction ; Percutaneous Coronary Intervention ; Postoperative Complications - blood ; Postoperative Complications - diagnosis ; Prognosis ; Prospective Studies ; Risk stratification ; ST Elevation Myocardial Infarction - blood ; ST Elevation Myocardial Infarction - surgery
É parte de: Circulation Journal, 2016/09/23, Vol.80(10), pp.2183-2191
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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Descrição: Background:MicroRNAs (miRNAs) are key players in cardiovascular development and disease. However, not only miRNAs of a cardiac origin have a critical role in heart function. Recent studies have demonstrated that miR-122-5p, a hepatic miRNA, increases in the bloodstream during ischemic cardiogenic shock and it is upregulated in the infarcted myocardium. The aim of the present study was to determine the potential of circulating miR-122-5p as a biomarker for early prognostic stratification of ST-segment elevation acute myocardial infarction (STEMI) patients.Methods and Results:One hundred and forty-two consecutive STEMI patients treated with primary angioplasty were included in the study. Serum levels of miR-1-3p, -122-5p, -133a-3p, -133b, -208b-3p and -499a-5p were measured at the time of cardiac catheterization by quantitative polymerase chain reaction and related to in-hospital and long-term outcome. During a follow up of 20.8 months, 9 patients died, 6 had recurrence of myocardial infarction, and 26 patients suffered an adverse cardiovascular event. Event-free survival was significantly worse in patients with a higher miR-122-5p/133b ratio (3rd tertile distribution, above 1.42 Log(10)), having almost a 9-fold higher risk of death or myocardial infarction and a 4-fold higher risk of adverse cardiovascular events.Conclusions:This study showed that the miR-122-5p/133b ratio is a new prognostic biomarker for the early identification of STEMI patients at a higher risk of developing major adverse events after undergoing primary percutaneous coronary intervention. (Circ J 2016; 80: 2183–2191)
Editor: Japan: The Japanese Circulation Society
Idioma: Inglês

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Circulating miR-122-5p/miR-133b Ratio Is a Specific Early Prognostic Biomarker in Acute Myocardial Infarction

Cortez-Dias, Nuno ; Costa, Marina C. ; Carrilho-Ferreira, Pedro ; Silva, Doroteia ; Jorge, Cláudia ; Calisto, Carina ; Pessoa, Teresa ; Martins, Susana Robalo ; Sousa, João Carvalho de ; Silva, Pedro Canas da ; Fiúza, Manuela ; Diogo, António Nunes ; Pinto, Fausto J. ; Enguita, Francisco J.

Japan: The Japanese Circulation Society

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