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Effects of brain ischemia on intermediate filaments of rat hippocampus

CAMARGO-DE-MORAIS, M ; DE FREITAS, M ; SOUZA, C. A. B ; PESSOA-PUREUR, R ; NETTO, C. A ; DE MATTOS, A. G ; SCHRÖDER, N ; ZILLES, A. C ; LISBOA, C. S. F ; ARTENI, N ; BARLEM, A ; SCHIERHOLT, R ; ZWETSCH, G

Neurochemical research, 1996-05, Vol.21 (5), p.595-602 [Periódico revisado por pares]

New York, NY: Springer

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Título:
Effects of brain ischemia on intermediate filaments of rat hippocampus
Autor: CAMARGO-DE-MORAIS, M ; DE FREITAS, M ; SOUZA, C. A. B ; PESSOA-PUREUR, R ; NETTO, C. A ; DE MATTOS, A. G ; SCHRÖDER, N ; ZILLES, A. C ; LISBOA, C. S. F ; ARTENI, N ; BARLEM, A ; SCHIERHOLT, R ; ZWETSCH, G
Assuntos: Animals ; Biological and medical sciences ; Carbon Radioisotopes ; Cytoskeletal Proteins - metabolism ; Glial Fibrillary Acidic Protein - biosynthesis ; Hippocampus - metabolism ; Ischemic Attack, Transient - metabolism ; Kinetics ; Leucine - metabolism ; Medical sciences ; Neurofilament Proteins - metabolism ; Neurology ; Phosphorus Radioisotopes ; Radioisotope Dilution Technique ; Rats ; Rats, Wistar ; Reperfusion ; Time Factors ; Vascular diseases and vascular malformations of the nervous system
É parte de: Neurochemical research, 1996-05, Vol.21 (5), p.595-602
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Neurofilaments subunits (NF-H, NF-M, NF-L) and glial fibrillary acidic protein (GFAP) were investigated in the hippocampus of rats after distinct periods of reperfusion (1 to 15 days) following 20 min of transient global forebrain ischemia in the rat. In vitro [14Ca]leucine incorporation was not altered until 48 h after the ischemic insult, however concentration of intermediate filament subunits significantly decreased in this period. Three days after the insult, leucine incorporation significantly increased while the concentration NF-H, NF-M, and NF-L were still diminished after 15 days of reperfusion. In vitro incorporation of 32P into NF-M and NF-L suffered immediately after ischemia, but returned to control values after two days of reperfusion. GFAP levels decreased immediately after ischemia but quickly recovered and significantly peaked from 7 to 10 days after the insult. These results suggest that transient ischemia followed by reperfusion causes proteolysis of intermediate filaments in the hippocampus, and the proteolysis could be facilitated by diminished phosphorylation levels of NF-M and NF-L.
Editor: New York, NY: Springer
Idioma: Inglês

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Effects of brain ischemia on intermediate filaments of rat hippocampus

CAMARGO-DE-MORAIS, M ; DE FREITAS, M ; SOUZA, C. A. B ; PESSOA-PUREUR, R ; NETTO, C. A ; DE MATTOS, A. G ; SCHRÖDER, N ; ZILLES, A. C ; LISBOA, C. S. F ; ARTENI, N ; BARLEM, A ; SCHIERHOLT, R ; ZWETSCH, G

New York, NY: Springer

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