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NLRs guard metabolism to coordinate pattern- and effector-triggered immunity

Zhai, Keran ; Liang, Di ; Li, Helin ; Jiao, Fangyuan ; Yan, Bingxiao ; Liu, Jing ; Lei, Ziyao ; Huang, Li ; Gong, Xiangyu ; Wang, Xin ; Miao, Jiashun ; Wang, Yichuan ; Liu, Ji-Yun ; Zhang, Lin ; Wang, Ertao ; Deng, Yiwen ; Wen, Chi-Kuang ; Guo, Hongwei ; Han, Bin ; He, Zuhua

Nature (London), 2022-01, Vol.601 (7892), p.245-251 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
NLRs guard metabolism to coordinate pattern- and effector-triggered immunity
Autor: Zhai, Keran ; Liang, Di ; Li, Helin ; Jiao, Fangyuan ; Yan, Bingxiao ; Liu, Jing ; Lei, Ziyao ; Huang, Li ; Gong, Xiangyu ; Wang, Xin ; Miao, Jiashun ; Wang, Yichuan ; Liu, Ji-Yun ; Zhang, Lin ; Wang, Ertao ; Deng, Yiwen ; Wen, Chi-Kuang ; Guo, Hongwei ; Han, Bin ; He, Zuhua
Assuntos: Biodegradation ; Biosynthesis ; Degradation ; Disease resistance ; Effectors ; Ethylene ; Gene expression ; Immune system ; Immunity ; Infections ; Leucine ; Metabolic pathways ; Metabolism ; Metabolites ; Methionine ; Nucleotides ; Oryza - genetics ; Oryza - microbiology ; Oryza sativa indica ; Oryza sativa japonica ; Pathogens ; Plant Diseases - microbiology ; Plant Immunity - genetics ; Plants ; Proteins ; Receptors ; Rice blast ; Signal Transduction - genetics ; Spectrum analysis
É parte de: Nature (London), 2022-01, Vol.601 (7892), p.245-251
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Pattern-triggered immunity (PTI) and effector-triggered immunity (ETI) in plants enable them to respond to pathogens by activating the production of defence metabolites that orchestrate immune responses . How the production of defence metabolites is promoted by immune receptors and coordinated with broad-spectrum resistance remains elusive. Here we identify the deubiquitinase PICI1 as an immunity hub for PTI and ETI in rice (Oryza sativa). PICI1 deubiquitinates and stabilizes methionine synthetases to activate methionine-mediated immunity principally through biosynthesis of the phytohormone ethylene. PICI1 is targeted for degradation by blast fungal effectors, including AvrPi9, to dampen PTI. Nucleotide-binding domain, leucine-rich-repeat-containing receptors (NLRs) in the plant immune system, such as PigmR, protect PICI1 from effector-mediated degradation to reboot the methionine-ethylene cascade. Natural variation in the PICI1 gene contributes to divergence in basal blast resistance between the rice subspecies indica and japonica. Thus, NLRs govern an arms race with effectors, using a competitive mode that hinges on a critical defence metabolic pathway to synchronize PTI with ETI and ensure broad-spectrum resistance.
Editor: England: Nature Publishing Group
Idioma: Inglês

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NLRs guard metabolism to coordinate pattern- and effector-triggered immunity

Zhai, Keran ; Liang, Di ; Li, Helin ; Jiao, Fangyuan ; Yan, Bingxiao ; Liu, Jing ; Lei, Ziyao ; Huang, Li ; Gong, Xiangyu ; Wang, Xin ; Miao, Jiashun ; Wang, Yichuan ; Liu, Ji-Yun ; Zhang, Lin ; Wang, Ertao ; Deng, Yiwen ; Wen, Chi-Kuang ; Guo, Hongwei ; Han, Bin ; He, Zuhua

England: Nature Publishing Group

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