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“True” Helicobacter pylori infection and non‐cardia gastric cancer: A pooled analysis within the Stomach Cancer Pooling (StoP) Project

Morais, Samantha ; Costa, Adriana ; Albuquerque, Gabriela ; Araújo, Natália ; Tsugane, Shoichiro ; Hidaka, Akihisa ; Hamada, Gerson Shigueaki ; Ye, Weimin ; Plymoth, Amelie ; Leja, Marcis ; Gasenko, Evita ; Zaridze, David ; Maximovich, Dmitry ; Malekzadeh, Reza ; Derakhshan, Mohammad H. ; Pelucchi, Claudio ; Negri, Eva ; Camargo, M. Constanza ; Curado, Maria Paula ; Vioque, Jesus ; Zhang, Zuo‐Feng ; La Vecchia, Carlo ; Boffetta, Paolo ; Lunet, Nuno

Helicobacter (Cambridge, Mass.), 2022-06, Vol.27 (3), p.e12883-n/a [Periódico revisado por pares]

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Título:
“True” Helicobacter pylori infection and non‐cardia gastric cancer: A pooled analysis within the Stomach Cancer Pooling (StoP) Project
Autor: Morais, Samantha ; Costa, Adriana ; Albuquerque, Gabriela ; Araújo, Natália ; Tsugane, Shoichiro ; Hidaka, Akihisa ; Hamada, Gerson Shigueaki ; Ye, Weimin ; Plymoth, Amelie ; Leja, Marcis ; Gasenko, Evita ; Zaridze, David ; Maximovich, Dmitry ; Malekzadeh, Reza ; Derakhshan, Mohammad H. ; Pelucchi, Claudio ; Negri, Eva ; Camargo, M. Constanza ; Curado, Maria Paula ; Vioque, Jesus ; Zhang, Zuo‐Feng ; La Vecchia, Carlo ; Boffetta, Paolo ; Lunet, Nuno
Assuntos: Algorithms ; Antibodies ; Atrophy ; Cancer ; Case-Control Studies ; Confidence intervals ; Consortium ; Enzyme-linked immunosorbent assay ; Epidemiology ; Estimates ; Gastric cancer ; Helicobacter Infections - complications ; Helicobacter Infections - epidemiology ; Helicobacter pylori ; Humans ; Infections ; International studies ; Medicin och hälsovetenskap ; pooled analysis ; Prospective Studies ; Reclassification ; Risk analysis ; Risk Factors ; Serology ; Stomach ; stomach neoplasms ; Stomach Neoplasms - etiology ; Trinucleotide repeats
É parte de: Helicobacter (Cambridge, Mass.), 2022-06, Vol.27 (3), p.e12883-n/a
Notas: Funding information
This study was funded by national funds from the Foundation for Science and Technology—FCT (Portuguese Ministry of Science, Technology and Higher Education), under the Unidade de Investigação em Epidemiologia—Instituto de Saúde Pública da Universidade do Porto (EPIUnit; UIDB/04750/2020), and by the Associazione Italiana per la Ricerca sul Cancro (AIRC), Project no. 21378 (Investigator Grant). AC and SM were funded by FEDER through the Operational Program Competitiveness and Internationalization, and national funding from FCT under the scope of the project "NEON‐PC—Neuro‐oncological complications of prostate cancer: longitudinal study of cognitive decline" (POCI‐01‐0145‐FEDER‐032358; ref. PTDC/SAU‐EPI/32358/2017). SM was also funded by the EPIUnit—Junior Research—Prog Financing (UIDP/04750/2020). An individual grant attributed to NA (SFRH/BD/119390/2016) was funded by FCT and the Programa Operacional Capital Humano (POCH/FSE). The authors thank the European Cancer Prevention Organization for providing support for the project meetings. The funding sources had no role in the study design; collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.
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Descrição: Background Helicobacter pylori is the most important risk factor for non‐cardia gastric cancer (NCGC); however, the magnitude of the association varies across epidemiological studies. This study aimed to quantify the association between H. pylori infection and NCGC, using different criteria to define infection status. Methods A pooled analysis of individual‐level H. pylori serology data from eight international studies (1325 NCGC and 3121 controls) from the Stomach Cancer Pooling (StoP) Consortium was performed. Cases and controls with a negative H. pylori infection status were reclassified as positive considering the presence of anti‐Cag A antibodies, gastric atrophy, or advanced stage at diagnosis, as available and applicable. A two‐stage approach was used to pool study‐specific adjusted odds ratios (OR), and 95% confidence intervals (95% CI). A meta‐analysis of published prospective studies assessing H. pylori seropositivity in NCGCs was conducted. Results The OR for the association between serology‐defined H. pylori and NCGC was 1.45 (95% CI: 0.87–2.42), which increased to 4.79 (95% CI: 2.39–9.60) following the reclassification of negative H. pylori infection. The results were consistent across strata of sociodemographic characteristics, clinical features and lifestyle factors, though significant differences were observed according to geographic region—a stronger association in Asian studies. The pooled risk estimates from the literature were 3.01 (95% CI: 2.22–4.07) for ELISA or EIA and 9.22 (95% CI: 3.12–27.21) for immunoblot or multiplex serology. Conclusion The NCGC risk estimate from StoP based on the reclassification of H. pylori seronegative individuals is consistent with the risk estimates obtained from the literature. Our classification algorithm may be useful for future studies.
Editor: England: Wiley Subscription Services, Inc
Idioma: Inglês

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“True” Helicobacter pylori infection and non‐cardia gastric cancer: A pooled analysis within the Stomach Cancer Pooling (StoP) Project

England: Wiley Subscription Services, Inc

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