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Oral and maxillofacial manifestations of chronic kidney disease–mineral and bone disorder: a multicenter retrospective study

Pontes, Flávia Sirotheau Corrêa ; Lopes, Márcio Ajudarte ; de Souza, Lucas Lacerda ; dos Santos da Mata Rezende, Diogo ; Santos-Silva, Alan Roger ; Jorge, Jacks ; da Silva, Wagner Gomes ; Pires, Fábio Ramôa ; Rocha, André Caroli ; de Campos, Wladimir Gushiken ; Caldato, Milena Coelho Fernandes ; Martin, Regina Matsunaga ; Fonseca, Felipe Paiva ; Pontes, Hélder Antônio Rebelo

Oral surgery, oral medicine, oral pathology and oral radiology, 2018-01, Vol.125 (1), p.31-43 [Periódico revisado por pares]

United States: Elsevier Inc

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  • Título:
    Oral and maxillofacial manifestations of chronic kidney disease–mineral and bone disorder: a multicenter retrospective study
  • Autor: Pontes, Flávia Sirotheau Corrêa ; Lopes, Márcio Ajudarte ; de Souza, Lucas Lacerda ; dos Santos da Mata Rezende, Diogo ; Santos-Silva, Alan Roger ; Jorge, Jacks ; da Silva, Wagner Gomes ; Pires, Fábio Ramôa ; Rocha, André Caroli ; de Campos, Wladimir Gushiken ; Caldato, Milena Coelho Fernandes ; Martin, Regina Matsunaga ; Fonseca, Felipe Paiva ; Pontes, Hélder Antônio Rebelo
  • Assuntos: Dentistry
  • É parte de: Oral surgery, oral medicine, oral pathology and oral radiology, 2018-01, Vol.125 (1), p.31-43
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: To describe the oral and maxillofacial manifestations of patients diagnosed with chronic kidney disease–mineral and bone disorders. Over a 13-year period, clinicopathologic data of patients diagnosed with CKD-MBD who had oral and maxillofacial alterations were retrieved from the files of 4 Brazilian institutions. Data included clinical, radiographic, microscopic, and biochemical findings; treatment employed; and follow-up status. Twenty-one cases were identified, with 13 patients diagnosed as brown tumor of hyperparathyroidism (BTH) and 8 as osteitis fibrosa/renal osteodystrophy (OF/RO) (4 of them clinically consistent with Sagliker syndrome). The mean age was 32.7 years, and the mandible was the most affected site (42.8%). OF/RO had an ill-defined “ground glass” radiographic appearance, and BTH produced well-defined radiolucent images. Biochemically the following mean values were obtained: parathormone 1511.07 pg/mL, calcium 9.25 mg/dL, phosphorus 5.19 mg/dL, alkaline phosphatase 941.55 U/L, urea 125.42 mg/dL, and creatinine 7.14 mg/dL. Treatment comprised vitamin D and calcium intake, parathyroidectomy, hemodialysis, renal transplantation, and local surgery. During follow-up, 5 patients with BTH were free of lesions, whereas 2 affected by OF/RO/Sagliker syndrome died. Oral and maxillofacial manifestations of BTH and OF/RO are uncommon, but they can be associated with an important life-threatening scenario.
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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