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Macroalgae Specialized Metabolites: Evidence for Their Anti-Inflammatory Health Benefits

Rocha, Djenisa H A ; Pinto, Diana C G A ; Silva, Artur M S

Marine drugs, 2022-12, Vol.20 (12), p.789 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Macroalgae Specialized Metabolites: Evidence for Their Anti-Inflammatory Health Benefits
Autor: Rocha, Djenisa H A ; Pinto, Diana C G A ; Silva, Artur M S
Assuntos: Algae ; anti-inflammatory ; Anti-inflammatory agents ; Anti-Inflammatory Agents - chemistry ; Anti-Inflammatory Agents - isolation & purification ; Anti-Inflammatory Agents - pharmacology ; Bioactive compounds ; bromophenols ; Cancer ; Cardiovascular disease ; Carotenoids ; chromenes ; Clinical trials ; Cosmetics ; Cyclooxygenase 2 - metabolism ; Cytokines ; Cytokines - metabolism ; Diseases ; Drug development ; Drugs ; Edema ; Enzyme inhibitors ; Enzymes ; Fatty acids ; Food ; Health aspects ; Health risks ; Heart diseases ; Humans ; Hydrocarbons ; Inflammation ; Inflammation - drug therapy ; Inflammatory diseases ; Kinases ; Metabolites ; Nitric oxide ; Nonsteroidal anti-inflammatory drugs ; phlorotannins ; Pigments ; Polyunsaturated fatty acids ; Prevention ; Proteins ; Receptors ; Respiratory diseases ; Respiratory disorders ; Review ; Rheumatoid arthritis ; seaweed ; Seaweed - chemistry ; Seaweed - metabolism ; Seaweeds ; Selectivity ; Side effects ; Signal transduction ; specialized metabolites ; Steroids ; Sterols ; Sustainable production ; Tumor necrosis factor-TNF
É parte de: Marine drugs, 2022-12, Vol.20 (12), p.789
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
Descrição: Inflammation is an organism's response to chemical or physical injury. It is split into acute and chronic inflammation and is the last, most significant cause of death worldwide. Nowadays, according to the World Health Organization (WHO), the greatest threat to human health is chronic disease. Worldwide, three out of five people die from chronic inflammatory diseases such as stroke, chronic respiratory diseases, heart disorders, and cancer. Nowadays, anti-inflammatory drugs (steroidal and non-steroidal, enzyme inhibitors that are essential in the inflammatory process, and receptor antagonists, among others) have been considered as promising treatments to be explored. However, there remains a significant proportion of patients who show poor or incomplete responses to these treatments or experience associated severe side effects. Seaweeds represent a valuable resource of bioactive compounds associated with anti-inflammatory effects and offer great potential for the development of new anti-inflammatory drugs. This review presents an overview of specialized metabolites isolated from seaweeds with in situ and in vivo anti-inflammatory properties. Phlorotannins, carotenoids, sterols, alkaloids, and polyunsaturated fatty acids present significant anti-inflammatory effects given that some of them are involved directly or indirectly in several inflammatory pathways. The majority of the isolated compounds inhibit the pro-inflammatory mediators/cytokines. Studies have suggested an excellent selectivity of chromene nucleus towards inducible pro-inflammatory COX-2 than its constitutive isoform COX-1. Additional research is needed to understand the mechanisms of action of seaweed's compounds in inflammation, given the production of sustainable and healthier anti-inflammatory agents.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Macroalgae Specialized Metabolites: Evidence for Their Anti-Inflammatory Health Benefits

Rocha, Djenisa H A ; Pinto, Diana C G A ; Silva, Artur M S

Switzerland: MDPI AG

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