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Airway Macrophages Mediate Mucosal Vaccine-Induced Trained Innate Immunity against Mycobacterium tuberculosis in Early Stages of Infection

D'Agostino, Michael R ; Lai, Rocky ; Afkhami, Sam ; Khera, Amandeep ; Yao, Yushi ; Vaseghi-Shanjani, Maryam ; Zganiacz, Anna ; Jeyanathan, Mangalakumari ; Xing, Zhou

The Journal of immunology (1950), 2020-11, Vol.205 (10), p.2750-2762 [Periódico revisado por pares]

United States

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Título:
Airway Macrophages Mediate Mucosal Vaccine-Induced Trained Innate Immunity against Mycobacterium tuberculosis in Early Stages of Infection
Autor: D'Agostino, Michael R ; Lai, Rocky ; Afkhami, Sam ; Khera, Amandeep ; Yao, Yushi ; Vaseghi-Shanjani, Maryam ; Zganiacz, Anna ; Jeyanathan, Mangalakumari ; Xing, Zhou
Assuntos: Administration, Mucosal ; Animals ; Bronchoalveolar Lavage Fluid - cytology ; Bronchoalveolar Lavage Fluid - immunology ; Disease Models, Animal ; Female ; Humans ; Immunity, Innate ; Macrophages, Alveolar - immunology ; Mice ; Mycobacterium tuberculosis - immunology ; Tuberculosis Vaccines - administration & dosage ; Tuberculosis Vaccines - immunology ; Tuberculosis, Pulmonary - diagnosis ; Tuberculosis, Pulmonary - immunology ; Tuberculosis, Pulmonary - microbiology ; Tuberculosis, Pulmonary - prevention & control ; Vaccines, Synthetic - administration & dosage ; Vaccines, Synthetic - immunology
É parte de: The Journal of immunology (1950), 2020-11, Vol.205 (10), p.2750-2762
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: , the causative agent of pulmonary tuberculosis (TB), is responsible for millions of infections and deaths annually. Decades of TB vaccine development have focused on adaptive T cell immunity, whereas the importance of innate immune contributions toward vaccine efficacy has only recently been recognized. Airway macrophages (AwM) are the predominant host cell during early pulmonary infection and, therefore, represent attractive targets for vaccine-mediated immunity. We have demonstrated that respiratory mucosal immunization with a viral-vectored vaccine imprints AwM, conferring enhanced protection against heterologous bacterial challenge. However, it is unknown if innate immune memory also protects against In this study, by using a murine model, we detail whether respiratory mucosal TB vaccination profoundly alters the airway innate immune landscape associated with AwM prior to exposure and whether such AwM play a critical role in host defense against infection. Our study reveals an important role of AwM in innate immune protection in early stages of infection in the lung.
Editor: United States
Idioma: Inglês

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Airway Macrophages Mediate Mucosal Vaccine-Induced Trained Innate Immunity against Mycobacterium tuberculosis in Early Stages of Infection

D'Agostino, Michael R ; Lai, Rocky ; Afkhami, Sam ; Khera, Amandeep ; Yao, Yushi ; Vaseghi-Shanjani, Maryam ; Zganiacz, Anna ; Jeyanathan, Mangalakumari ; Xing, Zhou

United States

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