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Plasticity of intrinsic neuronal excitability

Debanne, Dominique ; Inglebert, Yanis ; Russier, Michaël

Current opinion in neurobiology, 2019-02, Vol.54, p.73-82 [Periódico revisado por pares]

England: Elsevier Ltd

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  • Título:
    Plasticity of intrinsic neuronal excitability
  • Autor: Debanne, Dominique ; Inglebert, Yanis ; Russier, Michaël
  • Assuntos: Life Sciences ; Neurobiology ; Neurons and Cognition
  • É parte de: Current opinion in neurobiology, 2019-02, Vol.54, p.73-82
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: •Voltage-gated ion channels participate in memory formation.•Intrinsic plasticity is not only global but it might be also local.•Intrinsic plasticity shares common learning rules with synaptic plasticity.•GABAergic interneurons also express activity-dependent intrinsic plasticity.•Long-term plasticity of intrinsic excitability alters temporal processing. Long-term synaptic modification is not the exclusive mode of memory storage, and persistent regulation of voltage-gated ion channels also participates in memory formation. Intrinsic plasticity is expressed in virtually all neuronal types including principal cells and interneurons. Activation of synaptic glutamate receptors initiates long-lasting changes in neuronal excitability at presynaptic and postsynaptic side. As synaptic plasticity, intrinsic plasticity is bi-directional and expresses a certain level of input-specificity or cell-specificity. We discuss here the nature of the learning rules shared by intrinsic and synaptic plasticity and the impact of intrinsic plasticity on temporal processing.
  • Editor: England: Elsevier Ltd
  • Idioma: Inglês

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