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Long-Term Colorectal-Cancer Incidence and Mortality after Lower Endoscopy

Nishihara, Reiko ; Wu, Kana ; Lochhead, Paul ; Morikawa, Teppei ; Liao, Xiaoyun ; Qian, Zhi Rong ; Inamura, Kentaro ; Kim, Sun A ; Kuchiba, Aya ; Yamauchi, Mai ; Imamura, Yu ; Willett, Walter C ; Rosner, Bernard A ; Fuchs, Charles S ; Giovannucci, Edward ; Ogino, Shuji ; Chan, Andrew T

The New England journal of medicine, 2013-09, Vol.369 (12), p.1095-1105 [Periódico revisado por pares]

Waltham, MA: Massachusetts Medical Society

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Título:
Long-Term Colorectal-Cancer Incidence and Mortality after Lower Endoscopy
Autor: Nishihara, Reiko ; Wu, Kana ; Lochhead, Paul ; Morikawa, Teppei ; Liao, Xiaoyun ; Qian, Zhi Rong ; Inamura, Kentaro ; Kim, Sun A ; Kuchiba, Aya ; Yamauchi, Mai ; Imamura, Yu ; Willett, Walter C ; Rosner, Bernard A ; Fuchs, Charles S ; Giovannucci, Edward ; Ogino, Shuji ; Chan, Andrew T
Assuntos: Adenoma - diagnosis ; Adenoma - epidemiology ; Adenoma - mortality ; Adenoma - prevention & control ; Aged ; Biological and medical sciences ; Cancer screening ; Causes of ; Cohort Studies ; Colon cancer ; Colonic Polyps - genetics ; Colonic Polyps - pathology ; Colonoscopy ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - diagnosis ; Colorectal Neoplasms - epidemiology ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - prevention & control ; CpG islands ; DNA methylation ; DNA, Neoplasm - analysis ; Early Detection of Cancer ; Endoscopy ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; General aspects ; Humans ; Incidence ; Influence ; Male ; Medical personnel ; Medical sciences ; Microsatellite Instability ; Middle Aged ; Mortality ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Multivariate Analysis ; Mutation ; Phenotypes ; Sigmoidoscopy ; Statistical analysis ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors ; United States - epidemiology
É parte de: The New England journal of medicine, 2013-09, Vol.369 (12), p.1095-1105
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Drs. Nishihara, Wu, Lochhead, and Morikawa and Drs. Ogino and Chan contributed equally to this article.
Descrição: Among 88,902 participants followed over a period of 22 years in the Nurses' Health Study and the Health Professionals Follow-up Study, colon cancer mortality was reduced after screening sigmoidoscopy (hazard ratio, 0.59) and screening colonoscopy (hazard ratio, 0.32). Randomized, controlled trials have shown that screening with flexible sigmoidoscopy reduces the incidence of colorectal cancer and associated mortality, albeit with diminished effectiveness for cancers of the proximal colon. 1 – 3 Although comparable data from randomized, controlled trials of screening colonoscopy are not yet available, 4 colonoscopy is also widely endorsed by expert bodies for population-based screening, largely on the basis of case–control studies that show associations with reduced colorectal-cancer incidence and mortality. 5 – 9 However, as with flexible sigmoidoscopy, there is uncertainty about the effectiveness of colonoscopy in reducing the incidence of and mortality associated with proximal colon cancer 10 – 19 and about . . .
Editor: Waltham, MA: Massachusetts Medical Society
Idioma: Inglês

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Long-Term Colorectal-Cancer Incidence and Mortality after Lower Endoscopy

Nishihara, Reiko ; Wu, Kana ; Lochhead, Paul ; Morikawa, Teppei ; Liao, Xiaoyun ; Qian, Zhi Rong ; Inamura, Kentaro ; Kim, Sun A ; Kuchiba, Aya ; Yamauchi, Mai ; Imamura, Yu ; Willett, Walter C ; Rosner, Bernard A ; Fuchs, Charles S ; Giovannucci, Edward ; Ogino, Shuji ; Chan, Andrew T

Waltham, MA: Massachusetts Medical Society

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