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Concurrent exercise prevents high-fat-diet-induced macrovesicular hepatic steatosis

Gauthier, Marie-Soleil ; Couturier, Karine ; Latour, Jean-Gilles ; Lavoie, Jean-Marc

Journal of applied physiology (1985), 2003-06, Vol.94 (6), p.2127-2134 [Periódico revisado por pares]

Bethesda, MD: Am Physiological Soc

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  • Título:
    Concurrent exercise prevents high-fat-diet-induced macrovesicular hepatic steatosis
  • Autor: Gauthier, Marie-Soleil ; Couturier, Karine ; Latour, Jean-Gilles ; Lavoie, Jean-Marc
  • Assuntos: Animals ; Biological and medical sciences ; Diet ; Dietary Fats - administration & dosage ; Exercise ; Fatty Acids, Nonesterified - blood ; Fatty Liver - chemically induced ; Fatty Liver - prevention & control ; Female ; Fundamental and applied biological sciences. Psychology ; Insulin ; Lipid Metabolism ; Lipids ; Lipids - blood ; Liver ; Liver. Bile. Biliary tracts ; Motor Activity - physiology ; Oils & fats ; Physical Conditioning, Animal ; Rats ; Rats, Sprague-Dawley ; Vertebrates: digestive system
  • É parte de: Journal of applied physiology (1985), 2003-06, Vol.94 (6), p.2127-2134
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-1
    content type line 23
  • Descrição: Departments of Kinésiologie and Pathologie and Biologie Cellulaire, Université de Montréal, Montreal, Quebec, Canada H3C 3J7 The purpose of the present study was to assess the effect of an exercise training program conducted concurrently with a high-fat (HF)-diet regimen on the induction of hepatic steatosis. Two groups of rats were fed either a standard (SD) or a HF (40% kcal) diet for 8 wk and were additionally assigned either to a sedentary (Sed) or a treadmill-trained (TR) group. Training (5 days/wk) was initiated at the same time as the HF diet and was progressively increased, reaching 60 min at 26 m/min, 10% grade, for the last 4 wk. At the end of the 8-wk period, HF-Sed rats exhibited ~72% higher liver triacylglycerol concentration than SD-Sed rats (means   ± SE: 17.15 ± 1.5 vs. 9.98 ± 1.0 mg/g; P  < 0.01). Histological quantification of lipid infiltration, with the use of an image analysis computing system, revealed that, although fat was mainly stored as microvesicles (<1 µm 2 ), the HF-diet-induced hepatic steatosis occurred via the accumulation of macrovesicles (>1 µm 2 ). Concurrent exercise training completely prevented the HF-diet-induced hepatic steatosis. The surface area of liver parenchyma infiltrated by lipid vacuoles was similar in HF-TR as in SD-Sed rats (26.4   ± 1.8 vs. 29.3 ± 5.9 × 10 3 µm 2 /200,000 µm 2 of liver parenchyma, respectively; P  > 0.05). The different states of liver lipid infiltration after the HF diet in Sed and TR rats were associated with similar changes in plasma free fatty acids and glycerol, as well as with similar changes in fat pad weights, but not with plasma triacylglycerol levels. It is concluded that, after a HF-diet regimen of 8 wk in rats, hepatic steatosis occurs primarily via the accumulation of lipid as macrovesicles. Exercise training pursued at the same time completely prevents the HF-diet-induced macrovesicular hepatic steatosis. liver; fatty liver; lipid infiltration; lipid vacuoles; insulin resistance; adiposity
  • Editor: Bethesda, MD: Am Physiological Soc
  • Idioma: Inglês
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