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Effect of a Protective-Ventilation Strategy on Mortality in the Acute Respiratory Distress Syndrome

Amato, Marcelo Britto Passos ; Barbas, Carmen Silvia Valente ; Medeiros, Denise Machado ; Magaldi, Ricardo Borges ; Schettino, Guilherme Paula ; Lorenzi-Filho, Geraldo ; Kairalla, Ronaldo Adib ; Deheinzelin, Daniel ; Munoz, Carlos ; Oliveira, Roselaine ; Takagaki, Teresa Yae ; Carvalho, Carlos Roberto Ribeiro

The New England journal of medicine, 1998-02, Vol.338 (6), p.347-354 [Periódico revisado por pares]

Boston, MA: Massachusetts Medical Society

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Título:
Effect of a Protective-Ventilation Strategy on Mortality in the Acute Respiratory Distress Syndrome
Autor: Amato, Marcelo Britto Passos ; Barbas, Carmen Silvia Valente ; Medeiros, Denise Machado ; Magaldi, Ricardo Borges ; Schettino, Guilherme Paula ; Lorenzi-Filho, Geraldo ; Kairalla, Ronaldo Adib ; Deheinzelin, Daniel ; Munoz, Carlos ; Oliveira, Roselaine ; Takagaki, Teresa Yae ; Carvalho, Carlos Roberto Ribeiro
Assuntos: Acute respiratory distress syndrome ; Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Artificial respiration ; Barotrauma - etiology ; Barotrauma - prevention & control ; Biological and medical sciences ; Emergency and intensive respiratory care ; Humans ; Intensive care ; Intensive care medicine ; Lung Injury ; Medical sciences ; Methods ; Mortality ; Patient outcomes ; Patients ; Positive-Pressure Respiration - adverse effects ; Positive-Pressure Respiration - methods ; Proportional Hazards Models ; Pulmonary Ventilation ; Respiratory diseases ; Respiratory distress syndrome ; Respiratory Distress Syndrome, Adult - complications ; Respiratory Distress Syndrome, Adult - mortality ; Respiratory Distress Syndrome, Adult - therapy ; Respiratory system ; Respiratory therapy ; Risk ; Survival Analysis ; Tidal Volume ; Ventilation
É parte de: The New England journal of medicine, 1998-02, Vol.338 (6), p.347-354
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-News-3
content type line 23
Descrição: Mechanical ventilation can damage the lungs. 1 , 2 Lesions at the alveolar–capillary interface, 3 alterations in permeability, 4 and edema 5 – 7 have repeatedly been shown to occur in animals subjected to adverse patterns of mechanical ventilation. In clinical practice, however, the “mechanical stretch” caused by conventional ventilation has been found to be detrimental in only a few uncontrolled studies. 8 – 11 Large variations in the susceptibility of individual animal species 12 and the apparent success of mechanical ventilation based on a strategy of using the lowest positive end-expiratory pressure (PEEP) that results in acceptable oxygenation 13 , 14 suggest that the devastating effects observed in animals cannot . . .
Editor: Boston, MA: Massachusetts Medical Society
Idioma: Inglês

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Effect of a Protective-Ventilation Strategy on Mortality in the Acute Respiratory Distress Syndrome

Boston, MA: Massachusetts Medical Society

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