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Nerve-Sparing Radical Hysterectomy: Local Recurrence Rate, Feasibility, and Safety in Cervical Cancer Patients Stage IA to IIA

van den Tillaart, Sabrina A.H.M ; Kenter, Gemma G ; Peters, Alexander A.W ; Dekker, Friedo W ; Gaarenstroom, Katja N ; Fleuren, Gertjan J ; Trimbos, J Baptist M.Z

International journal of gynecological cancer, 2009-01, Vol.19 (1), p.39-45 [Periódico revisado por pares]

England: Lippincott Wiliams & Wilkins

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Título:
Nerve-Sparing Radical Hysterectomy: Local Recurrence Rate, Feasibility, and Safety in Cervical Cancer Patients Stage IA to IIA
Autor: van den Tillaart, Sabrina A.H.M ; Kenter, Gemma G ; Peters, Alexander A.W ; Dekker, Friedo W ; Gaarenstroom, Katja N ; Fleuren, Gertjan J ; Trimbos, J Baptist M.Z
Assuntos: Adenocarcinoma - pathology ; Adenocarcinoma - surgery ; Adult ; Aged ; Aged, 80 and over ; Bladder ; Cancer therapies ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - surgery ; Cervical cancer ; Feasibility Studies ; Female ; Follow-Up Studies ; Gynecology ; Humans ; Hysterectomy ; Hysterectomy - methods ; Lymphatic system ; Magnetic resonance imaging ; Metastasis ; Middle Aged ; Neoplasm Recurrence, Local - epidemiology ; Patients ; Radiation ; Statistical analysis ; Surgery ; Treatment Outcome ; Uterine Cervical Neoplasms - pathology ; Uterine Cervical Neoplasms - surgery
É parte de: International journal of gynecological cancer, 2009-01, Vol.19 (1), p.39-45
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: To clarify the debate about the possible threat of sparing the pelvic autonomic nerves in radical hysterectomy for cervical cancer to radicality, comparative studies of nerve-sparing and conventional surgery are necessary. The aim of his study was to analyze and compare local recurrence rate, feasibility, and safety of nerve-sparing and non-nerve-sparing radical hysterectomy. METHODS:In a cohort study with 2 years of follow-up, 246 patients with cervical cancer of stages IA to IIA were analyzed124 in the non-nerve-sparing group (1994-1999) and 122 in the group where nerve-sparing was the intention-to-treat (2001-2005). Local recurrence rate, local recurrence-free survival, feasibility, and safety were analyzed and compared. RESULTS:The clinical characteristics of the treatment groups were comparable. Sparing the nerves unilaterally or bilaterally was possible in 80% of cases of the nerve-sparing group. Local recurrence rates in the non-nerve-sparing (4.9%) and nerve-sparing (8.3%) group were not significantly different. Mean local recurrence-free survival within 2 years were 22.7 and 22.0 months, respectively. Univariate and multivariate regression analyses showed that nerve-sparing treatment was not a significant prognostic factor for local recurrence. With respect to perioperative and postoperative parameters, operating time and blood loss were less in the nerve-sparing group and mortality was equal (1 patient); the postoperative course of the nerve-sparing group was similar to the state-of-the-art of conventional radical hysterectomy. CONCLUSIONS:On the basis of the results of our study, we consider the nerve-sparing technique for cervical cancer stages IA to IIA feasible and safe.
Editor: England: Lippincott Wiliams & Wilkins
Idioma: Inglês

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Nerve-Sparing Radical Hysterectomy: Local Recurrence Rate, Feasibility, and Safety in Cervical Cancer Patients Stage IA to IIA

van den Tillaart, Sabrina A.H.M ; Kenter, Gemma G ; Peters, Alexander A.W ; Dekker, Friedo W ; Gaarenstroom, Katja N ; Fleuren, Gertjan J ; Trimbos, J Baptist M.Z

England: Lippincott Wiliams & Wilkins

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