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Brain manganese and the balance between essential roles and neurotoxicity

Balachandran, Rekha C. ; Mukhopadhyay, Somshuvra ; McBride, Danielle ; Veevers, Jennifer ; Harrison, Fiona E. ; Aschner, Michael ; Haynes, Erin N. ; Bowman, Aaron B.

The Journal of biological chemistry, 2020-05, Vol.295 (19), p.6312-6329 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Brain manganese and the balance between essential roles and neurotoxicity
Autor: Balachandran, Rekha C. ; Mukhopadhyay, Somshuvra ; McBride, Danielle ; Veevers, Jennifer ; Harrison, Fiona E. ; Aschner, Michael ; Haynes, Erin N. ; Bowman, Aaron B.
Assuntos: Animals ; brain ; Brain - metabolism ; Brain - pathology ; Cognition ; Homeostasis ; Humans ; JBC Reviews ; manganese ; Manganese - metabolism ; Manganese - toxicity ; metal ; metal homeostasis ; neurodegeneration ; neurodegenerative disease ; neurodevelopment ; Neurons - metabolism ; Neurons - pathology ; Neurotoxicity Syndromes - metabolism ; neurotoxin ; neurotransmitter ; toxicology
É parte de: The Journal of biological chemistry, 2020-05, Vol.295 (19), p.6312-6329
Notas: These authors contributed equally to this work.
Edited by Paul E. Fraser
Descrição: Manganese (Mn) is an essential micronutrient required for the normal development of many organs, including the brain. Although its roles as a cofactor in several enzymes and in maintaining optimal physiology are well-known, the overall biological functions of Mn are rather poorly understood. Alterations in body Mn status are associated with altered neuronal physiology and cognition in humans, and either overexposure or (more rarely) insufficiency can cause neurological dysfunction. The resultant balancing act can be viewed as a hormetic U-shaped relationship for biological Mn status and optimal brain health, with changes in the brain leading to physiological effects throughout the body and vice versa. This review discusses Mn homeostasis, biomarkers, molecular mechanisms of cellular transport, and neuropathological changes associated with disruptions of Mn homeostasis, especially in its excess, and identifies gaps in our understanding of the molecular and biochemical mechanisms underlying Mn homeostasis and neurotoxicity.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Brain manganese and the balance between essential roles and neurotoxicity

Balachandran, Rekha C. ; Mukhopadhyay, Somshuvra ; McBride, Danielle ; Veevers, Jennifer ; Harrison, Fiona E. ; Aschner, Michael ; Haynes, Erin N. ; Bowman, Aaron B.

United States: Elsevier Inc

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