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Level of Flt3-ligand in plasma: a possible new bio-indicator for radiation-induced aplasia

Bertho, C. Demarquay, J. Frick, C. Joubert, S. Arenales, N. Jacquet, I. Sorokine-Durm, Quang Chau, M. Lopez, J. Aigueperse, N.-C. Gorin, P. Gourmelon, J.-M.

International journal of radiation biology, 2001, Vol.77 (6), p.703-712 [Revista revisada por pares]

London: Informa UK Ltd

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Level of Flt3-ligand in plasma: a possible new bio-indicator for radiation-induced aplasia
Autor: Bertho, C. Demarquay, J. Frick, C. Joubert, S. Arenales, N. Jacquet, I. Sorokine-Durm, Quang Chau, M. Lopez, J. Aigueperse, N.-C. Gorin, P. Gourmelon, J.-M.
Materias: Animals ; Biological and medical sciences ; Biological effects of radiation ; Biomarkers - blood ; Bone Marrow - injuries ; Bone Marrow - radiation effects ; Bone Marrow Diseases - blood ; Bone Marrow Diseases - etiology ; Bone Marrow Diseases - therapy ; Bone Marrow Transplantation ; Circadian Rhythm ; Colony-Forming Units Assay ; Cross Reactions ; Female ; fms-Like Tyrosine Kinase 3 ; Fundamental and applied biological sciences. Psychology ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Ionizing radiations ; Leukocyte Count ; Macaca fascicularis ; Male ; Medical sciences ; Membrane Proteins - blood ; Membrane Proteins - immunology ; Miscellaneous. Technology ; Neutrophils ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Platelet Count ; Proto-Oncogene Proteins - immunology ; Radiation Injuries, Experimental - blood ; Radiation Injuries, Experimental - etiology ; Radiation Injuries, Experimental - therapy ; Receptor Protein-Tyrosine Kinases - immunology ; Tissues, organs and organisms biophysics ; Transplantation, Autologous ; Whole-Body Irradiation
Es parte de: International journal of radiation biology, 2001, Vol.77 (6), p.703-712
Descripción: Purpose : To follow plasma Flt3-ligand (FL) concentrations in irradiated animals in order to evaluate it as an indicator of bone marrow damage for the management of accidental radiation-induced aplasia. Materials and methods : Non-human primates were irradiated at doses ranging from 2 to 8 Gy, using whole- or partial-body irradiation. Plasma FL concentrations and blood cell counts were determined daily. Results : FL concentrations increased as early as day 2 after irradiation, whatever the irradiation dose. Increase in plasma FL concentration on day 5 post-irradiation was correlated with radiation dose and with the severity of radiation-induced aplasia. During the course of aplasia, FL concentrations in plasma were inversely correlated with neutrophil counts. A peak in FL concentration appeared before the neutrophil nadir, and the subsequent decrease in FL concentration was correlated with the recovery of blood-cell populations. Conclusions : Monitoring plasma FL concentration can be used as an indicator of radiation-induced marrow aplasia, and this may be of use in accidental irradiation situations.
Editor: London: Informa UK Ltd
Idioma: Inglés

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Level of Flt3-ligand in plasma: a possible new bio-indicator for radiation-induced aplasia

Bertho, C. Demarquay, J. Frick, C. Joubert, S. Arenales, N. Jacquet, I. Sorokine-Durm, Quang Chau, M. Lopez, J. Aigueperse, N.-C. Gorin, P. Gourmelon, J.-M.

London: Informa UK Ltd

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