Idioma:

Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes

Weng, Lu-Chen ; Benjamin, Emelia J ; Ellinor, Patrick T ; Kittner, Steven J ; Barnard, John ; Tucker, Nathan R ; Li, Molong ; Klarin, Derek ; Niemeijer, Maartje N ; Trompet, Stella ; Malik, Rainer ; Perez, Marco ; Aeschbacher, Stefanie ; Deo, Rajat ; Hopewell, Jemma C ; Kamatani, Yoichiro ; Hagemeijer, Yanick P ; Kubo, Michiaki ; Psaty, Bruce M ; Launer, Lenore J ; Waldenberger, Melanie ; Lichtner, Peter ; Hernesniemi, Jussi ; Lindgren, Cecilia M ; Ford, Ian ; Porteous, David ; Hocking, Lynne J ; Orho-Melander, Marju ; Denny, Joshua C ; Kriebel, Jennifer ; Darbar, Dawood ; Macfarlane, Peter W ; Heilmann, Stefanie ; Hofman, Albert ; Lin, Henry J ; Melander, Olle ; Lokki, Marja-Liisa ; Jukema, J. Wouter ; Smoller, Sylvia ; Sorkin, John ; Pikula, Aleksandra ; Rexrode, Kathryn ; Goldstein, Larry ; James, Michael Luke ; Breteler, Monique ; Sharma, Pankaj ; Tatlisumak, Turgot ; Bijlenga, Philippe ; Roquer, Jaume ; Cotlarcius, Ioana ; Hardy, John ; Korostynski, Michal ; Boncoraglio, Giorgio ; Parati, Eugenio ; Mateusz, Adamski ; Olszanecki, Rafael ; Juchniewicz, Karol Jozef ; Nyquist, Paul ; Franca, Paulo ; Keller, Lina ; Crisby, Milita ; Kostulas, Konstantinos ; Gonik, Mariya ; Staals, Julie ; Sadr-Nabavi, Ariane ; Falcone, Guido ; Brott, Thomas ; Enzinger, Christian ; Blanton, Susan ; Rundek, Tatjana ; Gschwendtner, Andreas ; Deng, Zhen ; Rothwell, Peter ; Lebedeva, Elena ; Jood, Katarina ; Lee, Chaeyoung ; Markus, Hugh ; Chern, Joseph ; Giraldo, Elias ; Stine, Colin ; Smalley, June ; Hansen, Bjorn ; Jose Martin, Juan ; Klijn, Karin ; Macleod, Mary ; Pezzini, Alessandro ; Padovani, Alessandro ; Cramer, Steve ; Broderick, Joseph ; Kissela, Brett ; Sudlow, Cathie ; Rannikmae, Kristiina ; McArdle, Patrick ; Giese, Anne-Katrin ; Majersik, Jennifer ; Cushman, Mary ; Psaty, Bruce ; Reiner, Alex ; Montaner, Joan ; Heitsch, Laura

NEUROLOGY-GENETICS, 2018-12, Vol.4 (6) [Periódico revisado por pares]

LIPPINCOTT WILLIAMS & WILKINS

Texto completo disponível

Citações Citado por

Enviar para

Título:
Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes
Autor: Weng, Lu-Chen ; Benjamin, Emelia J ; Ellinor, Patrick T ; Kittner, Steven J ; Barnard, John ; Tucker, Nathan R ; Li, Molong ; Klarin, Derek ; Niemeijer, Maartje N ; Trompet, Stella ; Malik, Rainer ; Perez, Marco ; Aeschbacher, Stefanie ; Deo, Rajat ; Hopewell, Jemma C ; Kamatani, Yoichiro ; Hagemeijer, Yanick P ; Kubo, Michiaki ; Psaty, Bruce M ; Launer, Lenore J ; Waldenberger, Melanie ; Lichtner, Peter ; Hernesniemi, Jussi ; Lindgren, Cecilia M ; Ford, Ian ; Porteous, David ; Hocking, Lynne J ; Orho-Melander, Marju ; Denny, Joshua C ; Kriebel, Jennifer ; Darbar, Dawood ; Macfarlane, Peter W ; Heilmann, Stefanie ; Hofman, Albert ; Lin, Henry J ; Melander, Olle ; Lokki, Marja-Liisa ; Jukema, J. Wouter ; Smoller, Sylvia ; Sorkin, John ; Pikula, Aleksandra ; Rexrode, Kathryn ; Goldstein, Larry ; James, Michael Luke ; Breteler, Monique ; Sharma, Pankaj ; Tatlisumak, Turgot ; Bijlenga, Philippe ; Roquer, Jaume ; Cotlarcius, Ioana ; Hardy, John ; Korostynski, Michal ; Boncoraglio, Giorgio ; Parati, Eugenio ; Mateusz, Adamski ; Olszanecki, Rafael ; Juchniewicz, Karol Jozef ; Nyquist, Paul ; Franca, Paulo ; Keller, Lina ; Crisby, Milita ; Kostulas, Konstantinos ; Gonik, Mariya ; Staals, Julie ; Sadr-Nabavi, Ariane ; Falcone, Guido ; Brott, Thomas ; Enzinger, Christian ; Blanton, Susan ; Rundek, Tatjana ; Gschwendtner, Andreas ; Deng, Zhen ; Rothwell, Peter ; Lebedeva, Elena ; Jood, Katarina ; Lee, Chaeyoung ; Markus, Hugh ; Chern, Joseph ; Giraldo, Elias ; Stine, Colin ; Smalley, June ; Hansen, Bjorn ; Jose Martin, Juan ; Klijn, Karin ; Macleod, Mary ; Pezzini, Alessandro ; Padovani, Alessandro ; Cramer, Steve ; Broderick, Joseph ; Kissela, Brett ; Sudlow, Cathie ; Rannikmae, Kristiina ; McArdle, Patrick ; Giese, Anne-Katrin ; Majersik, Jennifer ; Cushman, Mary ; Psaty, Bruce ; Reiner, Alex ; Montaner, Joan ; Heitsch, Laura
É parte de: NEUROLOGY-GENETICS, 2018-12, Vol.4 (6)
Descrição: OBJECTIVE: We sought to assess whether genetic risk factors for atrial fibrillation (AF) can explain cardioembolic stroke risk. METHODS: We evaluated genetic correlations between a previous genetic study of AF and AF in the presence of cardioembolic stroke using genome-wide genotypes from the Stroke Genetics Network (N = 3,190 AF cases, 3,000 cardioembolic stroke cases, and 28,026 referents). We tested whether a previously validated AF polygenic risk score (PRS) associated with cardioembolic and other stroke subtypes after accounting for AF clinical risk factors. RESULTS: We observed a strong correlation between previously reported genetic risk for AF, AF in the presence of stroke, and cardioembolic stroke (Pearson r = 0.77 and 0.76, respectively, across SNPs with p < 4.4 × 10-4 in the previous AF meta-analysis). An AF PRS, adjusted for clinical AF risk factors, was associated with cardioembolic stroke (odds ratio [OR] per SD = 1.40, p = 1.45 × 10-48), explaining ∼20% of the heritable component of cardioembolic stroke risk. The AF PRS was also associated with stroke of undetermined cause (OR per SD = 1.07, p = 0.004), but no other primary stroke subtypes (all p > 0.1). CONCLUSIONS: Genetic risk of AF is associated with cardioembolic stroke, independent of clinical risk factors. Studies are warranted to determine whether AF genetic risk can serve as a biomarker for strokes caused by AF.
Editor: LIPPINCOTT WILLIAMS & WILKINS
Idioma: Inglês

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes

LIPPINCOTT WILLIAMS & WILKINS

Buscando em bases de dados remotas. Favor aguardar.