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Improvements in diabetic albuminuria and podocyte differentiation following Roux-en-Y gastric bypass surgery

Canney, Aoife L ; Cohen, Ricardo V ; Elliott, Jessie A ; M Aboud, Cristina ; Martin, William P ; Docherty, Neil G ; le Roux, Carel W

Diabetes & vascular disease research, 2020-01, Vol.17 (1), p.1479164119879039-1479164119879039 [Periódico revisado por pares]

London, England: SAGE Publications

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Improvements in diabetic albuminuria and podocyte differentiation following Roux-en-Y gastric bypass surgery
Autor: Canney, Aoife L ; Cohen, Ricardo V ; Elliott, Jessie A ; M Aboud, Cristina ; Martin, William P ; Docherty, Neil G ; le Roux, Carel W
Assuntos: Aged ; Albuminuria - blood ; Albuminuria - etiology ; Albuminuria - pathology ; Animals ; Blood Glucose - metabolism ; Brief Report ; Cell Differentiation ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - diagnosis ; Diabetic Nephropathies - blood ; Diabetic Nephropathies - etiology ; Diabetic Nephropathies - pathology ; Disease Models, Animal ; Female ; Gastric Bypass ; Humans ; Male ; Obesity - complications ; Obesity - diagnosis ; Obesity - surgery ; Podocytes - pathology ; Prospective Studies ; Rats, Zucker ; Risk Factors ; Time Factors ; Treatment Outcome ; Weight Loss
É parte de: Diabetes & vascular disease research, 2020-01, Vol.17 (1), p.1479164119879039-1479164119879039
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Background: Multiple studies demonstrate an albuminuria-lowering impact of Roux-en-Y gastric bypass surgery, but neither evaluation of its penetrance across different baseline levels of albuminuria nor its association with alterations in podocyte phenotype has previously been reported. Methods: We profiled changes in body weight, glycaemic control and urinary albumin excretion following Roux-en-Y gastric bypass surgery in 105 patients with type 2 diabetes, albuminuria of varying degrees of severity and classified as being at moderate or high risk of chronic kidney disease progression according to the Kidney Disease: Improving Global Outcomes 2012 criteria. In parallel pre-clinical studies, the impact of Roux-en-Y gastric bypass surgery on markers of podocyte injury was assessed in the Zucker diabetic fatty rat model of diabetic kidney disease. Results: At 12- to 18-month post-operative follow-up in patients at moderate or high risk of chronic kidney disease, significant reductions in albuminuria were observed across all tertiles of baseline albumin–creatinine ratio, with remission of albuminuria occurring in 78% of patients. Relative to sham-operated control animals, weight loss and improvements in glycaemia following Roux-en-Y gastric bypass surgery in Zucker diabetic fatty rats were paralleled by normalisation of glomerular tuft-size, reductions in podocyte expression of desmin, and preservation of podocyte foot process morphology. Conclusion: Improvements in podocyte differentiation likely underpin the reductions in albuminuria observed following Roux-en-Y gastric bypass surgery.
Editor: London, England: SAGE Publications
Idioma: Inglês

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Improvements in diabetic albuminuria and podocyte differentiation following Roux-en-Y gastric bypass surgery

Canney, Aoife L ; Cohen, Ricardo V ; Elliott, Jessie A ; M Aboud, Cristina ; Martin, William P ; Docherty, Neil G ; le Roux, Carel W

London, England: SAGE Publications

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