skip to main content
Idioma:
Tipo de recurso Mostra resultados com: Mostra resultados com: Índice

Meta-analysis Shows That Prevalence of Epstein–Barr Virus-Positive Gastric Cancer Differs Based on Sex and Anatomic Location

Murphy, Gwen ; Pfeiffer, Ruth ; Camargo, M. Constanza ; Rabkin, Charles S

Gastroenterology (New York, N.Y. 1943), 2009-09, Vol.137 (3), p.824-833 [Periódico revisado por pares]

United States: Elsevier Inc

Texto completo disponível

Citações Citado por
  • Título:
    Meta-analysis Shows That Prevalence of Epstein–Barr Virus-Positive Gastric Cancer Differs Based on Sex and Anatomic Location
  • Autor: Murphy, Gwen ; Pfeiffer, Ruth ; Camargo, M. Constanza ; Rabkin, Charles S
  • Assuntos: Adenocarcinoma - virology ; Carcinoma - virology ; Cardia - virology ; Epstein-Barr Virus Infections - complications ; Female ; Gastric Stump ; Gastroenterology and Hepatology ; Herpesvirus 4, Human - isolation & purification ; Humans ; Male ; Pyloric Antrum - virology ; Sex Factors ; Stomach Neoplasms - pathology ; Stomach Neoplasms - surgery ; Stomach Neoplasms - virology
  • É parte de: Gastroenterology (New York, N.Y. 1943), 2009-09, Vol.137 (3), p.824-833
  • Descrição: Background & Aims Epstein–Barr virus (EBV) has been causally associated with cancer; some gastric carcinomas have a monoclonal EBV genome in every cancer cell, indicating that they arose from a single infected progenitor cell. However, the proportion of EBV-positive gastric carcinomas is uncertain, and the etiologic significance is unknown. Methods We conducted a meta-analysis of 70 studies including 15,952 cases of gastric cancer assessed by in situ hybridization for EBV-encoded small RNA. Results The pooled prevalence estimate of EBV positivity was 8.7% (95% confidence interval [CI]: 7.5%–10.0%) overall, with a 2-fold difference by sex: 11.1% (95% CI: 8.7%–14.1%) of gastric cancer cases in males vs 5.2% (95% CI: 3.6%–7.4%) of cases in females. Tumors arising in the gastric cardia (13.6%) or corpus (13.1%) were more than twice as likely to be EBV-positive as those in the antrum (5.2%; P < .01 for both comparisons). EBV prevalence was 4 times higher (35.1%) for tumors in postsurgical gastric stump/remnants. Over 90% of lymphoepithelioma-like carcinomas were EBV positive, but only 15 studies reported any cases of this type; prevalence did not significantly differ between the more common diffuse (7.6%) and intestinal (9.5%) histologies. EBV prevalence was similar in cases from Asia (8.3%), Europe (9.2%), and the Americas (9.9%). Conclusions EBV-positive gastric cancers greatly differ from other gastric carcinomas based on sex, anatomic subsite, and surgically disrupted anatomy, indicating that it is a distinct etiologic entity. Epidemiologic studies comparing EBV-positive and -negative gastric cancers are warranted to investigate EBV's role in gastric carcinogenesis.
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.