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Motor skill learning requires active central myelination

McKenzie, Ian A. ; Ohayon, David ; Li, Huiliang ; de Faria, Joana Paes ; Emery, Ben ; Tohyama, Koujiro ; Richardson, William D.

Science (American Association for the Advancement of Science), 2014-10, Vol.346 (6207), p.318-322 [Periódico revisado por pares]

United States: American Association for the Advancement of Science

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Título:
Motor skill learning requires active central myelination
Autor: McKenzie, Ian A. ; Ohayon, David ; Li, Huiliang ; de Faria, Joana Paes ; Emery, Ben ; Tohyama, Koujiro ; Richardson, William D.
Assuntos: Adults ; Animals ; Bars ; Brain ; Brain - cytology ; Brain - metabolism ; Cell Proliferation ; Cognition & reasoning ; Gene Deletion ; Humans ; Learning ; Male ; Mental Recall ; Mice ; Mice, Transgenic ; Motor ability ; Motor Skills - physiology ; Myelin ; Myelin Sheath - genetics ; Myelin Sheath - metabolism ; Oligodendroglia - cytology ; Oligodendroglia - metabolism ; Oligodendroglia - physiology ; Psychomotor Skills ; RESEARCH ARTICLE ; Running ; Skill Development ; Synaptic Transmission ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Wheels
É parte de: Science (American Association for the Advancement of Science), 2014-10, Vol.346 (6207), p.318-322
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Present address: Instituto de Biologia Molecular e Celular, Rua do Campo Alegre 823, 4150-180 Porto, Portugal.
Descrição: Myelin-forming oligodendrocytes (OLs) are formed continuously in the healthy adult brain. In this work, we study the function of these late-forming cells and the myelin they produce. Learning a new motor skill (such as juggling) alters the structure of the brain’s white matter, which contains many OLs, suggesting that late-born OLs might contribute to motor learning. Consistent with this idea, we show that production of newly formed OLs is briefly accelerated in mice that learn a new skill (running on a “complex wheel” with irregularly spaced rungs). By genetically manipulating the transcription factor myelin regulatory factor in OL precursors, we blocked production of new OLs during adulthood without affecting preexisting OLs or myelin. This prevented the mice from mastering the complex wheel. Thus, generation of new OLs and myelin is important for learning motor skills.
Editor: United States: American Association for the Advancement of Science
Idioma: Inglês

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Motor skill learning requires active central myelination

McKenzie, Ian A. ; Ohayon, David ; Li, Huiliang ; de Faria, Joana Paes ; Emery, Ben ; Tohyama, Koujiro ; Richardson, William D.

United States: American Association for the Advancement of Science

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