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Precise Two‐Photon Photodynamic Therapy using an Efficient Photosensitizer with Aggregation‐Induced Emission Characteristics

Gu, Bobo ; Wu, Wenbo ; Xu, Gaixia ; Feng, Guangxue ; Yin, Feng ; Chong, Peter Han Joo ; Qu, Junle ; Yong, Ken‐Tye ; Liu, Bin

Advanced materials (Weinheim), 2017-07, Vol.29 (28), p.n/a [Periódico revisado por pares]

Germany: Wiley Subscription Services, Inc

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Título:
Precise Two‐Photon Photodynamic Therapy using an Efficient Photosensitizer with Aggregation‐Induced Emission Characteristics
Autor: Gu, Bobo ; Wu, Wenbo ; Xu, Gaixia ; Feng, Guangxue ; Yin, Feng ; Chong, Peter Han Joo ; Qu, Junle ; Yong, Ken‐Tye ; Liu, Bin
Assuntos: Ablation ; Absorption cross sections ; Agglomeration ; aggregation‐induced emission ; Animals ; Biocompatibility ; Biocompatible Materials - chemistry ; Biocompatible Materials - pharmacology ; Biocompatible Materials - therapeutic use ; Block copolymers ; Blood Vessels - diagnostic imaging ; Brain ; brain‐blood‐vessel closure ; cancer cells ; Cell Survival - drug effects ; Chemical synthesis ; Emission ; Encapsulation ; Excitation ; Fluoresceins - chemistry ; Fluorescence ; HeLa Cells ; Humans ; In vitro methods and tests ; Light ; Mice ; Microscopy, Fluorescence ; Photochemotherapy ; Photodynamic therapy ; Photon absorption ; Photons ; Photosensitizing Agents - chemistry ; Photosensitizing Agents - pharmacology ; Photosensitizing Agents - therapeutic use ; Polymers - chemistry ; Quantum Dots - chemistry ; Reactive Oxygen Species - metabolism ; two‐photon excitation ; Vascular Diseases - drug therapy ; Wound Healing - drug effects
É parte de: Advanced materials (Weinheim), 2017-07, Vol.29 (28), p.n/a
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SourceType-Scholarly Journals-1
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Descrição: Two‐photon photodynamic therapy (PDT) is able to offer precise 3D manipulation of treatment volumes, providing a target level that is unattainable with current therapeutic techniques. The advancement of this technique is greatly hampered by the availability of photosensitizers with large two‐photon absorption (TPA) cross section, high reactive‐oxygen‐species (ROS) generation efficiency, and bright two‐photon fluorescence. Here, an effective photosensitizer with aggregation‐induced emission (AIE) characteristics is synthesized, characterized, and encapsulated into an amphiphilic block copolymer to form organic dots for two‐photon PDT applications. The AIE dots possess large TPA cross section, high ROS generation efficiency, and excellent photostability and biocompatibility, which overcomes the limitations of many conventional two‐photon photosensitizers. Outstanding therapeutic performance of the AIE dots in two‐photon PDT is demonstrated using in vitro cancer cell ablation and in vivo brain‐blood‐vessel closure as examples. This shows therapy precision up to 5 µm under two‐photon excitation. A new two‐photon photosensitizer is synthesized and formulated into organic dots with aggregation‐induced emission characteristics, large two‐photon absorption cross section, high reactive‐oxygen‐species generation efficiency, and excellent photostability and biocompatibility, enabling in vitro cancer cell ablation and in vivo brain‐blood‐vessel closure with 5 µm precision under two‐photon excitation.
Editor: Germany: Wiley Subscription Services, Inc
Idioma: Inglês

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Precise Two‐Photon Photodynamic Therapy using an Efficient Photosensitizer with Aggregation‐Induced Emission Characteristics

Gu, Bobo ; Wu, Wenbo ; Xu, Gaixia ; Feng, Guangxue ; Yin, Feng ; Chong, Peter Han Joo ; Qu, Junle ; Yong, Ken‐Tye ; Liu, Bin

Germany: Wiley Subscription Services, Inc

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