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Zinc sensing and regulation in yeast model systems

Wilson, Stevin ; Bird, Amanda J.

Archives of biochemistry and biophysics, 2016-12, Vol.611, p.30-36 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Zinc sensing and regulation in yeast model systems
Autor: Wilson, Stevin ; Bird, Amanda J.
Assuntos: Gene Expression Regulation, Fungal ; Homeostasis ; Loz1 ; Nutrient ; Protein Domains ; Saccharomyces cerevisiae - metabolism ; Saccharomyces cerevisiae Proteins - metabolism ; Schizosaccharomyces - metabolism ; Schizosaccharomyces pombe Proteins - metabolism ; Transcription ; Transcription Factors - metabolism ; Transcription, Genetic ; Transcriptional Activation ; Yeast ; Zap1 ; Zinc - chemistry ; Zinc Fingers ; Zinc homeostasis
É parte de: Archives of biochemistry and biophysics, 2016-12, Vol.611, p.30-36
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: The Zap1 transcription factor of Saccharomyces cerevisiae and the Loz1 transcription factor of Schizosaccharomyces pombe both play a central role in zinc homeostasis by controlling the expression of genes necessary for zinc metabolism. Zap1 activates gene expression when cells are limited for zinc, while Loz1 is required for gene repression when zinc is in excess. In this review we highlight what is known about the underlying mechanisms by which these factors are regulated by zinc, and how transcriptional activation and repression in eukaryotic cells can be finely tuned according to intracellular zinc availability. •Zap1 is a transcription factor from Saccharomyces cerevisiae that activates gene expression in zinc-limited cells.•Zap1 is regulated at both a transcriptional and post-translational level by zinc.•Zap1 contains three zinc-responsive domains that independently detect changes in intracellular zinc levels.•Loz1 is a transcription factor from Schizosaccharomyces pombe that represses gene expression in zinc-replete cells.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Zinc sensing and regulation in yeast model systems

Wilson, Stevin ; Bird, Amanda J.

United States: Elsevier Inc

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