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The Role of Cellular Adaptation to Mechanical Forces in Atherosclerosis

Hahn, Cornelia ; Schwartz, Martin A

Arteriosclerosis, thrombosis, and vascular biology, 2008-12, Vol.28 (12), p.2101-2107 [Periódico revisado por pares]

Philadelphia, PA: American Heart Association, Inc

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Título:
The Role of Cellular Adaptation to Mechanical Forces in Atherosclerosis
Autor: Hahn, Cornelia ; Schwartz, Martin A
Assuntos: Adaptation, Physiological ; Animals ; Associated diseases and complications ; Atherosclerosis (general aspects, experimental research) ; Atherosclerosis - physiopathology ; Biological and medical sciences ; Biomechanical Phenomena ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Diabetes. Impaired glucose tolerance ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Endothelial Cells - physiology ; Extracellular Matrix - physiology ; Humans ; Inflammation - physiopathology ; Mechanotransduction, Cellular ; Medical sciences ; Membrane Fluidity ; Models, Cardiovascular ; Myocytes, Smooth Muscle - physiology ; Reactive Oxygen Species - metabolism ; Signal Transduction
É parte de: Arteriosclerosis, thrombosis, and vascular biology, 2008-12, Vol.28 (12), p.2101-2107
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Descrição: Atherosclerosis is a chronic inflammatory disease that originates at regions of arteries exposed to disturbances in fluid flow and results in progressive plaque formation in those areas. Recent work on cellular responses to flow has identified potential mechanosensors and pathways that may influence disease progression. These results led us to hypothesize that the same mechanisms that mediate adaptive responses in the vasculature become maladaptive at sites of disturbed flow. Subsequent changes in gene expression and matrix remodeling help to entrain these inflammatory pathways. These events synergize with systemic risk factors such as hyperlipidemia, smoking, and diabetes, leading to disease progression.
Editor: Philadelphia, PA: American Heart Association, Inc
Idioma: Inglês

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The Role of Cellular Adaptation to Mechanical Forces in Atherosclerosis

Hahn, Cornelia ; Schwartz, Martin A

Philadelphia, PA: American Heart Association, Inc

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