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Drug‐induced photosensitivity: new insights into pathomechanisms and clinical variation through basic and applied science

Khandpur, S. ; Porter, R.M. ; Boulton, S.J. ; Anstey, A.

British journal of dermatology (1951), 2017-04, Vol.176 (4), p.902-909 [Periódico revisado por pares]

England: Oxford University Press

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Título:
Drug‐induced photosensitivity: new insights into pathomechanisms and clinical variation through basic and applied science
Autor: Khandpur, S. ; Porter, R.M. ; Boulton, S.J. ; Anstey, A.
Assuntos: Apoptosis - drug effects ; Dermatitis, Photoallergic - etiology ; Dermatitis, Phototoxic - etiology ; Drug development ; Drugs ; Early Diagnosis ; Humans ; Hyperpigmentation - chemically induced ; Keratinocytes - physiology ; Pain ; Pain - chemically induced ; Pellagra - chemically induced ; Photodermatitis ; Photosensitivity ; Photosensitivity Disorders - chemically induced ; Photosensitivity Disorders - diagnosis ; Photosensitivity Disorders - therapy ; Phototoxicity ; Porphyrias - chemically induced ; Reactive oxygen species ; Reactive Oxygen Species - pharmacology ; Skin Pigmentation - drug effects ; Sunburn - etiology ; Ultraviolet radiation
É parte de: British journal of dermatology (1951), 2017-04, Vol.176 (4), p.902-909
Notas: Conflicts of interest
Funding sources
Commonwealth Clinical Fellowship to S.K.
None declared.
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Descrição: Summary Drug‐induced photosensitivity occurs when a drug is capable of absorbing radiation from the sun (usually ultraviolet A) leading to chemical reactions that cause cellular damage (phototoxicity) or, more rarely, form photoallergens (photoallergy). The manifestation varies considerably in presentation and severity from mild pain to severe blistering. Despite screening strategies and guidelines in place to predict photoreactive drugs during development there are still new drugs coming onto the market that cause photosensitivity. Thus, there is a continuing need for dermatologists to be aware of the different forms of presentation and the culprit drugs. Management usually involves photoprotection and cessation of drug treatment. However, there are always cases where the culprit drug is indispensable. The reason why some patients are susceptible while others remain asymptomatic is not known. A potential mechanism for the phototoxic reactions is the generation of reactive oxygen species (ROS), and there are a number of reasons why some patients might be less able to cope with enhanced levels of ROS. What's already known about this topic? Drugs that can absorb light (mostly ultraviolet A) can lead to photosensitivity in some patients. A potential mechanism for phototoxicity is via the generation of higher levels of reactive oxygen species (ROS). What does this study add? Despite measures to test drugs for potential photoreactivity, new drugs are still emerging that can cause photosensitivity. There are a number of reasons why some patients may not cope with the increased ROS levels that could explain their susceptibility to drug‐induced photosensitivity. Linked Comment: Ibbotson. Br J Dermatol 2017; 176:850–851
Editor: England: Oxford University Press
Idioma: Inglês

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Drug‐induced photosensitivity: new insights into pathomechanisms and clinical variation through basic and applied science

Khandpur, S. ; Porter, R.M. ; Boulton, S.J. ; Anstey, A.

England: Oxford University Press

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