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LC–MS/MS Quantitative Determination of Tetrapterys mucronata Alkaloids, a Plant Occasionally used in Ayahuasca Preparation

Queiroz, M. M. F ; Marti, G ; Queiroz, E. F ; Marcourt, L ; Castro‐Gamboa, I ; Bolzani, V. S ; Wolfender, J.‐L

Phytochemical analysis, 2015-05, Vol.26 (3), p.183-188 [Periódico revisado por pares]

England: Wiley

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Título:
LC–MS/MS Quantitative Determination of Tetrapterys mucronata Alkaloids, a Plant Occasionally used in Ayahuasca Preparation
Autor: Queiroz, M. M. F ; Marti, G ; Queiroz, E. F ; Marcourt, L ; Castro‐Gamboa, I ; Bolzani, V. S ; Wolfender, J.‐L
Assuntos: 5-methoxy-bufotenine ; alkaloids ; Alkaloids - analysis ; Alkaloids - chemistry ; ayahuasca ; bark ; Brazil ; Bufotenin - analogs & derivatives ; Bufotenin - analysis ; bufotenine ; Carbolines - analysis ; Chromatography, High Pressure Liquid - methods ; ethanol ; Hallucinogens - chemistry ; high performance liquid chromatography ; HPLC-ESI/MS/MS quantitation ; ingredients ; ionization ; Life Sciences ; Malpighiaceae ; Malpighiaceae - chemistry ; monitoring ; Plant Bark - chemistry ; quantitative analysis ; risk ; Serotonin - analogs & derivatives ; Serotonin - analysis ; Spectrometry, Mass, Electrospray Ionization - methods ; Tandem Mass Spectrometry - methods ; Tetrapterys mucronata ; toxicity ; tryptamine
É parte de: Phytochemical analysis, 2015-05, Vol.26 (3), p.183-188
Notas: http://dx.doi.org/10.1002/pca.2548
Supporting info item
istex:B5165C51F04DDC029AEAAA9C5F5BA7C61A7BF72F
ark:/67375/WNG-QD4WNX5S-F
ArticleID:PCA2548
Descrição: INTRODUCTION: Tetrapterys mucronata Cav. (Malpighiaceae) is a plant used in some regions of Brazil in the preparation of ayahuasca. OBJECTIVE: To determine the content of the main tryptamine alkaloids in the stem bark of T. mucronata Cav. and assess their possible toxic and hallucinogenic properties based on the doses found in a water decoction that mimics the ayahuasca preparation. METHODS: Four alkaloids previously described for their toxic and hallucinogenic properties were quantitated by multiple reaction monitoring HPLC combined with electrospray ionisation and tandem MS (HPLC–ESI/MS/MS) in the water decoction and ethanolic extracts from the bark of T. mucronata. RESULTS: Exhaustive extraction of the stem barks with ethanol revealed the following alkaloid levels: bufotenine (1) 3.26 ± 0.31 mg/g, 5‐methoxy‐N‐methyltryptamine (2) 0.88 ± 0.08 mg/g, 5‐methoxy‐bufotenine (3) 3.07 ± 0.22 mg/g and 2‐methyl‐6‐methoxy‐1,2,3,4‐tetrahydro‐β‐carboline (4) 0.14 ± 0.004 mg/g. The water decoction presented slightly lower levels, ranging between 2.32 ± 0.14, 0.50 ± 0.04, 1.53 ± 0.09 and 0.10 ± 0.01 mg/g for (1), (2), (3) and (4) respectively. CONCLUSIONS: The HPLC–ESI/MS/MS quantitation revealed significant alkaloid levels, in particular for bufotenine and 5‐methoxy‐bufotenine. As such compounds are known for their toxic and hallucinogenic properties, these results indicate that the consumption of this plant as an ingredient in ayahuasca preparations may present a risk to consumers. Copyright © 2015 John Wiley & Sons, Ltd.
Editor: England: Wiley
Idioma: Inglês

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LC–MS/MS Quantitative Determination of Tetrapterys mucronata Alkaloids, a Plant Occasionally used in Ayahuasca Preparation

Queiroz, M. M. F ; Marti, G ; Queiroz, E. F ; Marcourt, L ; Castro‐Gamboa, I ; Bolzani, V. S ; Wolfender, J.‐L

England: Wiley

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