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Association of left ventricular abnormalities with incident cerebrovascular events and sources of thromboembolism in patients with chronic Chagas cardiomyopathy

Moreira, Henrique Turin ; Volpe, Gustavo Jardim ; Mesquita, Gustavo Marques ; Braggion-Santos, Maria Fernanda ; Pazin-Filho, Antonio ; Marin-Neto, José Antonio ; Schmidt, André

Journal of cardiovascular magnetic resonance, 2022-11, Vol.24 (1), p.52-52, Article 52 [Periódico revisado por pares]

England: BioMed Central Ltd

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Título:
Association of left ventricular abnormalities with incident cerebrovascular events and sources of thromboembolism in patients with chronic Chagas cardiomyopathy
Autor: Moreira, Henrique Turin ; Volpe, Gustavo Jardim ; Mesquita, Gustavo Marques ; Braggion-Santos, Maria Fernanda ; Pazin-Filho, Antonio ; Marin-Neto, José Antonio ; Schmidt, André
Assuntos: Abnormalities ; Aneurysms ; Atrial Fibrillation ; Atrial Flutter ; Blood clots ; Cardiac arrhythmia ; Cardiomyopathies ; Cardiomyopathy ; Cardiovascular disease ; Care and treatment ; Chagas Cardiomyopathy - complications ; Chagas Cardiomyopathy - diagnostic imaging ; Chagas Cardiomyopathy - epidemiology ; Chagas disease ; Female ; Fibrosis ; Flutter ; Health risks ; Heart ; Heart Diseases ; Humans ; Infections ; Ischemia ; Left ventricular dysfunction ; Magnetic resonance ; Magnetic resonance imaging ; Male ; Middle Aged ; Predictive Value of Tests ; Retrospective Studies ; Risk analysis ; Risk factors ; Stroke ; Stroke (Disease) ; Stroke Volume ; Thromboembolism ; Thromboembolism - diagnostic imaging ; Thromboembolism - epidemiology ; Thromboembolism - etiology ; Thrombosis ; Transient ischemic attack ; Vector-borne diseases ; Ventricle ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Dysfunction, Left - epidemiology ; Ventricular Dysfunction, Left - etiology ; Ventricular Function, Left ; Vibration
É parte de: Journal of cardiovascular magnetic resonance, 2022-11, Vol.24 (1), p.52-52, Article 52
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Although Chagas cardiomyopathy is related to thromboembolic stroke, data on risk factors for cerebrovascular events in Chagas disease is limited. Thus, we assessed the relationship between left ventricular (LV) impairment and cerebrovascular events and sources of thromboembolism in patients with Chagas cardiomyopathy. This retrospective cohort included patients with chronic Chagas cardiomyopathy who underwent cardiovascular magnetic resonance (CMR). CMR was performed with a 1.5 T scanner to provide LV volumes, mass, ejection fraction (LVEF), and myocardial fibrosis. The primary outcome was a composite of incident ischemic cerebrovascular events (stroke or transient ischemic attack-TIA) and potential thromboembolic sources (atrial fibrillation (AF), atrial flutter, or intracavitary thrombus) during the follow-up. A total of 113 patients were included. Median age was 56 years (IQR: 45-67), and 58 (51%) were women. The median LVEF was 53% (IQR: 41-62). LV aneurysms and LV fibrosis were present in 38 (34%) and 76 (67%) individuals, respectively. The median follow-up time was 6.9 years, with 29 events: 11 cerebrovascular events, 16 had AF or atrial flutter, and two had LV apical thrombosis. In the multivariable model, only lower LVEF remained significantly associated with the outcomes (HR: 0.96, 95% CI: 0.93-0.99). Patients with reduced LVEF lower than 40% had a much higher risk of cerebrovascular events and thromboembolic sources (HR: 3.16 95% CI: 1.38-7.25) than those with normal LVEF. The combined incidence rate of the combined events in chronic Chagas cardiomyopathy patients with reduced LVEF was 13.9 new cases per 100 persons-year. LV systolic dysfunction is an independent predictor of adverse cerebrovascular events and potential sources of thromboembolism in patients with chronic Chagas cardiomyopathy.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Association of left ventricular abnormalities with incident cerebrovascular events and sources of thromboembolism in patients with chronic Chagas cardiomyopathy

Moreira, Henrique Turin ; Volpe, Gustavo Jardim ; Mesquita, Gustavo Marques ; Braggion-Santos, Maria Fernanda ; Pazin-Filho, Antonio ; Marin-Neto, José Antonio ; Schmidt, André

England: BioMed Central Ltd

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