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Previous exercise attenuates muscle sympathetic activity and increases blood flow during acute euglycemic hyperinsulinemia

Bisquolo, V. A. F ; Cardoso, C. G., Jr ; Ortega, K. C ; Gusmao, J. L ; Tinucci, T ; Negrao, C. E ; Wajchenberg, B. L ; Mion, D., Jr ; Forjaz, C. L. M

Journal of applied physiology (1985), 2005-03, Vol.98 (3), p.866-871 [Periódico revisado por pares]

Bethesda, MD: Am Physiological Soc

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Título:
Previous exercise attenuates muscle sympathetic activity and increases blood flow during acute euglycemic hyperinsulinemia
Autor: Bisquolo, V. A. F ; Cardoso, C. G., Jr ; Ortega, K. C ; Gusmao, J. L ; Tinucci, T ; Negrao, C. E ; Wajchenberg, B. L ; Mion, D., Jr ; Forjaz, C. L. M
Assuntos: Acute Disease ; Adult ; Biological and medical sciences ; Blood Flow Velocity ; Blood Glucose - analysis ; Circulatory system ; Exercise ; Exercise Test ; Fundamental and applied biological sciences. Psychology ; Glucose Clamp Technique - methods ; Humans ; Hyperinsulinism - physiopathology ; Insulin ; Insulin - blood ; Male ; Muscle, Skeletal - blood supply ; Muscle, Skeletal - innervation ; Muscle, Skeletal - physiopathology ; Muscular system ; Nervous system ; Physical Endurance ; Sympathetic Nervous System - physiopathology ; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports
É parte de: Journal of applied physiology (1985), 2005-03, Vol.98 (3), p.866-871
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-News-3
Descrição: 1 Exercise Hemodynamic Laboratory, School of Physical Education and Sport, 2 Hypertension Unit, General Hospital, 3 Endocrinology Division, General Hospital, 4 Unit of Cardiovascular Rehabilitation and Exercise Physiology, Heart Institute (InCor), Medical School, and 5 Experimental Physiopathology Division, Medical School, University of São Paulo, Brazil Submitted 8 March 2004 ; accepted in final form 29 October 2004 Insulin infusion causes muscle vasodilation, despite the increase in sympathetic nerve activity. In contrast, a single bout of exercise decreases sympathetic activity and increases muscle blood flow during the postexercise period. We tested the hypothesis that muscle sympathetic activity would be lower and muscle vasodilation would be higher during hyperinsulinemia performed after a single bout of dynamic exercise. Twenty-one healthy young men randomly underwent two hyperinsulinemic euglycemic clamps performed after 45 min of seated rest (control) or bicycle exercise (50% of peak oxygen uptake). Muscle sympathetic nerve activity (MSNA, microneurography), forearm blood flow (FBF, plethysmography), blood pressure (BP, oscillometric method), and heart rate (HR, ECG) were measured at baseline (90 min after exercise or seated rest) and during hyperinsulinemic euglycemic clamps. Baseline glucose and insulin concentrations were similar in the exercise and control sessions. Insulin sensitivity was unchanged by previous exercise. During the clamp, insulin levels increased similarly in both sessions. As expected, insulin infusion increased MSNA, FBF, BP, and HR in both sessions (23 ± 1 vs. 36 ± 2 bursts/min, 1.8 ± 0.1 vs. 2.2 ± 0.2 ml·min 1 ·100 ml 1 , 89 ± 2 vs. 92 ± 2 mmHg, and 58 ± 1 vs. 62 ± 1 beats/min, respectively, P < 0.05). BP and HR were similar between sessions. However, MSNA was significantly lower (27 ± 2 vs. 31 ± 2 bursts/min), and FBF was significantly higher (2.2 ± 0.2 vs. 1.8 ± 0.1 ml·min 1 ·100 ml 1 , P < 0.05) in the exercise session compared with the control session. In conclusion, in healthy men, a prolonged bout of dynamic exercise decreases MSNA and increases FBF. These effects persist during acute hyperinsulinemia performed after exercise. insulin infusion; physical exercise; blood pressure; muscle sympathetic nerve activity; muscle blood flow Address for reprint requests and other correspondence: Lúcia de Moraes Forjaz, Av. Prof. Mello de Moraes, 65, Butantã, São Paulo, SP 05508-900, Brasil (E-mail: cforjaz{at}usp.br )
Editor: Bethesda, MD: Am Physiological Soc
Idioma: Inglês

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Previous exercise attenuates muscle sympathetic activity and increases blood flow during acute euglycemic hyperinsulinemia

Bisquolo, V. A. F ; Cardoso, C. G., Jr ; Ortega, K. C ; Gusmao, J. L ; Tinucci, T ; Negrao, C. E ; Wajchenberg, B. L ; Mion, D., Jr ; Forjaz, C. L. M

Bethesda, MD: Am Physiological Soc

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