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Interleukin-17 inhibits adult hippocampal neurogenesis

Liu, Qiang ; Xin, Wei ; He, Ping ; Turner, Dharshaun ; Yin, Junxiang ; Gan, Yan ; Shi, Fu-Dong ; Wu, Jie

Scientific reports, 2014-12, Vol.4, p.7554-7554 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Interleukin-17 inhibits adult hippocampal neurogenesis
Autor: Liu, Qiang ; Xin, Wei ; He, Ping ; Turner, Dharshaun ; Yin, Junxiang ; Gan, Yan ; Shi, Fu-Dong ; Wu, Jie
Assuntos: Animals ; Clonal deletion ; Cytokines ; Dentate gyrus ; Dentate Gyrus - cytology ; Dentate Gyrus - growth & development ; Excitability ; Gene Deletion ; Hippocampus ; Inflammation ; Interleukin 17 ; Interleukin-17 - genetics ; Interleukin-17 - metabolism ; Mice ; Mice, Knockout ; Neural stem cells ; Neural Stem Cells - cytology ; Neural Stem Cells - metabolism ; Neurogenesis ; Neurogenesis - physiology ; Synaptic transmission ; Synaptic Transmission - physiology
É parte de: Scientific reports, 2014-12, Vol.4, p.7554-7554
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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These authors contributed equally to this work.
Descrição: Interleukin 17(A) (IL-17) is a potent pro-inflammatory cytokine that acts as a central regulator of inflammatory response within the brain, but its physiological roles under non-inflammatory conditions remain elusive. Here we report that endogenous IL-17 ablates neurogenesis in the adult dentate gyrus (DG) of hippocampus. Genetic deletion of IL-17 increased the number of adult-born neurons in the DG. Further, we found that IL-17 deletion altered cytokine network, facilitated basal excitatory synaptic transmission, enhanced intrinsic neuronal excitability, and increased expression of proneuronal genes in neuronal progenitor cells (NPCs). Our findings suggest a profound role of IL-17 in the negative regulation of adult hippocampal neurogenesis under physiology conditions.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Interleukin-17 inhibits adult hippocampal neurogenesis

Liu, Qiang ; Xin, Wei ; He, Ping ; Turner, Dharshaun ; Yin, Junxiang ; Gan, Yan ; Shi, Fu-Dong ; Wu, Jie

England: Nature Publishing Group

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