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Acute toxicity, antinociceptive, and anti-inflammatory activities of the orally administered crotamine in mice

Moreira, Lorena A. ; Oliveira, Lanussy P. ; Magalhães, Marta R. ; Oliveira, Sayonara A. M. ; Oliveira-Neto, Jerônimo R. ; Carvalho, Pablinny M. G. ; Carvalho, Adryano A. V. ; Fajemiroye, James O. ; Cruz, Alessandro C. ; Cunha, Luiz C.

Naunyn-Schmiedeberg's archives of pharmacology, 2021-08, Vol.394 (8), p.1703-1711 [Periódico revisado por pares]

Berlin/Heidelberg: Springer Berlin Heidelberg

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Título:
Acute toxicity, antinociceptive, and anti-inflammatory activities of the orally administered crotamine in mice
Autor: Moreira, Lorena A. ; Oliveira, Lanussy P. ; Magalhães, Marta R. ; Oliveira, Sayonara A. M. ; Oliveira-Neto, Jerônimo R. ; Carvalho, Pablinny M. G. ; Carvalho, Adryano A. V. ; Fajemiroye, James O. ; Cruz, Alessandro C. ; Cunha, Luiz C.
Assuntos: Acetic acid ; Acute toxicity ; Administration, Oral ; Analgesics - administration & dosage ; Analgesics - pharmacology ; Analgesics - toxicity ; Animals ; Anti-Inflammatory Agents - administration & dosage ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - toxicity ; Biomedical and Life Sciences ; Biomedicine ; Carrageenan ; Crotalid Venoms - administration & dosage ; Crotalid Venoms - pharmacology ; Crotalid Venoms - toxicity ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Ear ; Edema ; Edema - drug therapy ; Edema - pathology ; Inflammation ; Intoxication ; Lethality ; Leukocyte migration ; Leukocytes (neutrophilic) ; Male ; Mice ; Neurosciences ; Oral administration ; Original Article ; Pain ; Pain - drug therapy ; Pain perception ; Pharmacology/Toxicology ; Pleurisy ; Pleurisy - drug therapy ; Pleurisy - pathology ; Toxicity Tests, Acute ; Venom
É parte de: Naunyn-Schmiedeberg's archives of pharmacology, 2021-08, Vol.394 (8), p.1703-1711
Descrição: Crotamine is a polypeptide toxin isolated from rattlesnake venom. Although several studies have been developed identifying many biological effects of isolated crotamine, none of them evaluated its acute toxicity, antinociceptive, and anti-inflammatory activities through oral administration. All in vivo experiments from this study were performed in mice. The up-and-down procedure and hippocratic screening were carried out to evaluate possible pharmacological and toxic effects. Antinociceptive and anti-inflammatory activities of this toxin were evaluated using acetic acid-induced abdominal writhing, formalin-induced pain assays, croton oil-induced ear edema, and carrageenan-induced pleurisy. Crotamine did not cause lethality or signs of intoxication up to the maximum dose tested (10.88 mg/kg). The number of contortions was reduced significantly by 34, 57, and 74% at the oral doses of 0.08, 0.16, and 0.32 mg/kg, respectively. At the dose of 0.16 mg/kg, crotamine decreases pain time-reactivity at neurogenic phase by 45% and at inflammatory phase by 60%. Also, crotamine elicited antiedematogenic activity through the attenuation of the croton oil-induced ear edema by 77%. In the carrageenan-induced pleurisy, the leukocyte, neutrophil, and mononuclear cell migration to the lesion site were reduced by 52%, 46%, and 59%, respectively. Altogether, crotamine demonstrated in vivo antinociceptive and anti-inflammatory effect through acute oral administration, generating an anti-migratory mechanism of action at non-toxic doses.
Editor: Berlin/Heidelberg: Springer Berlin Heidelberg
Idioma: Inglês

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Acute toxicity, antinociceptive, and anti-inflammatory activities of the orally administered crotamine in mice

Moreira, Lorena A. ; Oliveira, Lanussy P. ; Magalhães, Marta R. ; Oliveira, Sayonara A. M. ; Oliveira-Neto, Jerônimo R. ; Carvalho, Pablinny M. G. ; Carvalho, Adryano A. V. ; Fajemiroye, James O. ; Cruz, Alessandro C. ; Cunha, Luiz C.

Berlin/Heidelberg: Springer Berlin Heidelberg

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