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Clinical differences between invasive pulmonary infection by Scedosporium apiospermum and invasive pulmonary aspergillosis

Castón, J. J. ; Linares, M. J. ; Rivero, A. ; Casal, M. ; Torre-Cisneros, J.

Mycoses, 2011-09, Vol.54 (5), p.e468-e473 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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Título:
Clinical differences between invasive pulmonary infection by Scedosporium apiospermum and invasive pulmonary aspergillosis
Autor: Castón, J. J. ; Linares, M. J. ; Rivero, A. ; Casal, M. ; Torre-Cisneros, J.
Assuntos: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Amphotericin B ; Amphotericin B - administration & dosage ; Antifungal Agents - administration & dosage ; Aspergillosis ; Aspergillus ; Aspergillus - isolation & purification ; Aspergillus - pathogenicity ; CD4 antigen ; Cell number ; Chemoprevention - methods ; Child ; Child, Preschool ; Cohort Studies ; Diagnosis, Differential ; Female ; fungal infection ; Graft rejection ; Humans ; Immunosuppression ; Infection ; Intravenous administration ; Lung ; Lung Diseases, Fungal - microbiology ; Lung Diseases, Fungal - pathology ; Male ; Middle Aged ; Mycoses - diagnosis ; Mycoses - microbiology ; Mycoses - pathology ; Organ Transplantation - adverse effects ; Prophylaxis ; Prospective Studies ; risk factor ; Risk Factors ; Scedosporium - isolation & purification ; Scedosporium - pathogenicity ; Scedosporium apiospermum ; Scedosporium spp ; transplantation ; Young Adult
É parte de: Mycoses, 2011-09, Vol.54 (5), p.e468-e473
Notas: ark:/67375/WNG-DR3WPZQM-G
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Descrição: Summary Invasive pulmonary infection by Scedosporium apiospermum (IPSA) and invasive pulmonary aspergillosis (IPA) are clinically similar. Our objective was to identify clinical parameters that may differentiate IPSA from IPA. Ours was a prospective cohort study that included patients with different degrees of immunosuppression and respiratory isolation of S. apiospermum (SCA). Episodes of invasive infection were classified according to the EORTC and MSG criteria. Clinical variables corresponding to patients with IPSA were compared with those collected from patients with a diagnosis of IPA during the same period. Twenty‐seven patients with positive culture for SCA from respiratory samples were evaluated. Of the 27 positive cultures, nine were classified as IPSA. When compared with the 89 patients with IPA, patients with IPSA were most likely to have received prophylaxis with either aerosolised (14.6% vs. 66.7%; P < 0.001) or intravenous amphotericin B (AMB; 4.5% vs. 44.4%; P = 0.002), to have prior episode of acute rejection (19% vs. 66.7%; P = 0.005), to have a later onset of infection after transplantation (251 days vs. 404 days; P = 0.009), and to have higher CD4+ lymphocyte count (207.6 vs. 289.4; P = 0.005). Late‐onset disease after transplantation and prophylaxis with AMB are more frequent in patients with IPSA compared with IPA.
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês;Alemão

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Clinical differences between invasive pulmonary infection by Scedosporium apiospermum and invasive pulmonary aspergillosis

Castón, J. J. ; Linares, M. J. ; Rivero, A. ; Casal, M. ; Torre-Cisneros, J.

Oxford, UK: Blackwell Publishing Ltd

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