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Busulfan therapy of central nervous system xenografts in athymic mice

AARON, R. H ; ELION, G. B ; COLVIN, O. M ; GRAHAM, M ; KEIR, S ; BIGNER, D. D ; FRIEDMAN, H. S

Cancer chemotherapy and pharmacology, 1994, Vol.35 (2), p.127-131 [Periódico revisado por pares]

Berlin: Springer

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Título:
Busulfan therapy of central nervous system xenografts in athymic mice
Autor: AARON, R. H ; ELION, G. B ; COLVIN, O. M ; GRAHAM, M ; KEIR, S ; BIGNER, D. D ; FRIEDMAN, H. S
Assuntos: Animals ; Antineoplastic agents ; Biological and medical sciences ; Brain Neoplasms - drug therapy ; Brain Neoplasms - pathology ; Busulfan - therapeutic use ; Chemotherapy ; Child, Preschool ; Cyclophosphamide - analogs & derivatives ; Cyclophosphamide - therapeutic use ; Female ; Humans ; Injections, Intraperitoneal ; Male ; Medical sciences ; Medulloblastoma - drug therapy ; Medulloblastoma - pathology ; Melphalan - therapeutic use ; Mice ; Mice, Nude ; Neoplasm Transplantation ; Pharmacology. Drug treatments ; Transplantation, Heterologous ; Tumor Cells, Cultured
É parte de: Cancer chemotherapy and pharmacology, 1994, Vol.35 (2), p.127-131
Descrição: We evaluated the antitumor activity of busulfan against a panel of tumor cell lines and xenografts in athymic nude mice derived from childhood high-grade glioma, adult high-grade glioma, ependymoma, and medulloblastoma. Busulfan displayed similar activity against a panel of four medulloblastoma cell lines (D283 Med, Daoy, D341 Med, and D425 Med) and four corresponding sublines with laboratory-generated or clinically acquired resistance to 4-hydroperoxycyclophosphamide [D283 Med (4-HCR), Daoy (4-HCR), D341 Med (4-HCR), and D458 Med] and cross-resistance to melphalan. This is consistent with a nearly total lack of cross-resistance of busulfan to 4-hydroperoxycyclophosphamide. Busulfan was active in the therapy of all but one of the subcutaneous xenografts tested, with growth delays ranging from 14.3 days in D612 EP to 58.4 days in D528 EP. Busulfan produced statistically significant increases in the median survival of mice bearing intracranial D456 MG (66%-90%), D612 EP (18%-33%), and D528 EP (89%) xenografts. These studies suggest that busulfan may be active against medulloblastomas, high-grade gliomas, and ependymomas as well as against cyclophosphamide-resistant neoplasms.
Editor: Berlin: Springer
Idioma: Inglês

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Busulfan therapy of central nervous system xenografts in athymic mice

AARON, R. H ; ELION, G. B ; COLVIN, O. M ; GRAHAM, M ; KEIR, S ; BIGNER, D. D ; FRIEDMAN, H. S

Berlin: Springer

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