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Endostatin a Potential Biomarker for Heart Failure with Preserved Ejection Fraction

Barroso, Michael Coll ; Boehme, Philip ; Kramer, Frank ; Mondritzki, Thomas ; Koehler, Till ; Gülker, Jan-Erik ; Karoff, Martin ; Dinh, Wilfried

Arquivos brasileiros de cardiologia, 2017-11, Vol.109 (5), p.448-456 [Periódico revisado por pares]

Brazil: Sociedade Brasileira de Cardiologia - SBC

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  • Título:
    Endostatin a Potential Biomarker for Heart Failure with Preserved Ejection Fraction
  • Autor: Barroso, Michael Coll ; Boehme, Philip ; Kramer, Frank ; Mondritzki, Thomas ; Koehler, Till ; Gülker, Jan-Erik ; Karoff, Martin ; Dinh, Wilfried
  • Assuntos: Biomarcadores ; CARDIAC & CARDIOVASCULAR SYSTEMS ; Endostatinas ; Insuficiência Cardíaca ; Original ; Peptídeos Natriuréticos ; Volume Sistólico
  • É parte de: Arquivos brasileiros de cardiologia, 2017-11, Vol.109 (5), p.448-456
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
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  • Descrição: Endostatin is a circulating endogenous angiogenesis inhibitor preventing neovascularization. Previous studies demonstrated the prognostic value of Endostatin among patients with heart failure with reduced ejection fraction (HFrEF). However, the role of Endostatin among patients with heart failure with preserved ejection fraction (HFpEF) remains unclear. This study aimed to investigate the association between serum Endostatin levels, natriuretic peptide levels and the severity of left ventricular diastolic dysfunction and the diagnosis of HFpEF. Endostatin serum concentrations were measured in 301 patients comprising 77 HFpEF patients, 169 patients with asymptomatic left ventricular diastolic dysfunction (ALVDD), and 55 controls with normal cardiac function. Endostatin serum levels were significantly elevated in patients with HFpEF (median/interquartile range 179.0 [159-220]) and ALVDD (163.8 [145.4-191.3]) compared to controls (149.1 [130.6-176.9]), p < 0.001 and p = 0.004, respectively) and significant correlated with N-terminal pro B-type natriuretic peptide (NT-proBNP). This hypothesis-generating pilot study gives first evidence that Endostatin correlates with the severity of diastolic dysfunction and may become a novel biomarker for HFpEF. We hypothesize a rise in Endostatin levels may reflect inhibition of adaptive angiogenesis and adverse cardiac remodeling.
  • Editor: Brazil: Sociedade Brasileira de Cardiologia - SBC
  • Idioma: Inglês;Português
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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