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Postoperative External Irradiation and Prognostic Parameters in Stage I Endometrial Carcinoma: CLINICAL AND HISTOPATHOLOGIC STUDY OF 540 PATIENTS

AALDERS, JAN ; ABELER, VERA ; KOLSTAD, PER ; ONSRUD, MATHIAS

Obstetrics and gynecology (New York. 1953), 1980-10, Vol.56 (4), p.419-427 [Periódico revisado por pares]

United States: The American College of Obstetricians and Gynecologists

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  • Título:
    Postoperative External Irradiation and Prognostic Parameters in Stage I Endometrial Carcinoma: CLINICAL AND HISTOPATHOLOGIC STUDY OF 540 PATIENTS
  • Autor: AALDERS, JAN ; ABELER, VERA ; KOLSTAD, PER ; ONSRUD, MATHIAS
  • Assuntos: Adenocarcinoma - mortality ; Adenocarcinoma - radiotherapy ; Adenocarcinoma - surgery ; Clinical Trials as Topic ; Female ; Humans ; Lymphatic Metastasis ; Middle Aged ; Prognosis ; Prospective Studies ; Time Factors ; Uterine Neoplasms - mortality ; Uterine Neoplasms - radiotherapy ; Uterine Neoplasms - surgery ; Vaginal Neoplasms - secondary
  • É parte de: Obstetrics and gynecology (New York. 1953), 1980-10, Vol.56 (4), p.419-427
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-1
    ObjectType-News-3
    content type line 23
  • Descrição: From 1968 to 1974, 540 patients with stage I adenocarcinoma of the corpus uteri entered a prospective clinical trial to evaluate the effect of postoperative external pelvic irradiation. After primary surgery all patients received intravaginal radium irradiation; 6000 rads was delivered to the surface of the vaginal mucosa. At the time vaginal radium was given, randomization was performedGroup A received no further treatment (controls); group B received additional high-voltage irradiation to the pelvic field with a dose of 4000 rads to the pelvic lymph nodes. During the follow-up period of 3 to 10 years a significant reduction in vaginal and pelvic recurrences was found in group B as compared with group A (1.9 versus 6.9%, P<.01). On the other hand, more patients in group B developed distant metastases than those in group A (9.9 versus 5.4%). Thus, the 5-year survival rate was not improved by external irradiation. A more detailed analysis of the series led to the conclusion that only patients with poorly differentiated tumors (grade 3), which infiltrate more than half the myometrial thickness, might benefit from additional external radiotherapy. In almost 20% of 151 consecutive patients, tumor cells were found in endothelial lined spaces. Significantly more deaths and recurrences were found among these patients compared to those without vessel invasion (26.7 versus 9.1%, P<.01). (Obstet Gynecol 56:419, 1980)
  • Editor: United States: The American College of Obstetricians and Gynecologists
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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