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Cellular uptake and cytotoxicity of solid lipid nanospheres (SLN) incorporating doxorubicin or paclitaxel

Miglietta, Antonella ; Cavalli, Roberta ; Bocca, Claudia ; Gabriel, Ludovica ; Rosa Gasco, Maria

International journal of pharmaceutics, 2000-12, Vol.210 (1), p.61-67 [Periódico revisado por pares]

Amsterdam: Elsevier B.V

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Título:
Cellular uptake and cytotoxicity of solid lipid nanospheres (SLN) incorporating doxorubicin or paclitaxel
Autor: Miglietta, Antonella ; Cavalli, Roberta ; Bocca, Claudia ; Gabriel, Ludovica ; Rosa Gasco, Maria
Assuntos: Antibiotics, Antineoplastic - metabolism ; Antibiotics, Antineoplastic - pharmacology ; Antineoplastic agents ; Antineoplastic Agents, Phytogenic - metabolism ; Antineoplastic Agents, Phytogenic - pharmacology ; Biological and medical sciences ; Cell Survival - drug effects ; Cellular uptake ; Chemistry, Pharmaceutical ; Chemotherapy ; Cytotoxicity ; Doxorubicin - metabolism ; Doxorubicin - pharmacology ; Doxorubicin-loaded solid lipid nanospheres ; Fluorescent Dyes ; General pharmacology ; HL-60 Cells ; Humans ; Medical sciences ; Microscopy, Fluorescence ; Microspheres ; Paclitaxel - metabolism ; Paclitaxel - pharmacology ; Paclitaxel-loaded solid lipid nanospheres ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Tumor Cells, Cultured
É parte de: International journal of pharmaceutics, 2000-12, Vol.210 (1), p.61-67
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Solid Lipid Nanospheres (SLN) are colloidal therapeutic systems proposed for several administration routes and obtained by dispersing warm microemulsions in cold water. SLN as carriers of doxorubicin and paclitaxel have been previously studied. In this study, the cellular uptake of SLN and the cytotoxicity of doxorubicin and paclitaxel incorporated into SLN were investigated on two cell-lines, human promyelocytic leukemia (HL60) and human breast carcinoma (MCF-7). Cellular uptake of SLN was determined by incorporating 6-coumarin as fluorescent marker. The cellular uptake of fluorescent SLN was clearly evidenced by fluorescence microscopy. The cytotoxicity of doxorubicin incorporated in SLN was higher compared to the conventional doxorubicin solution, even at the lower concentrations. Paclitaxel in SLN was about 100-fold more effective than free paclitaxel on MCF-7 cells, while on HL60 cells a lower sensitivity was achieved with paclitaxel in SLN. Unloaded SLN had no cytotoxic effect on HL60 and MCF-7 cells.
Editor: Amsterdam: Elsevier B.V
Idioma: Inglês

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Cellular uptake and cytotoxicity of solid lipid nanospheres (SLN) incorporating doxorubicin or paclitaxel

Miglietta, Antonella ; Cavalli, Roberta ; Bocca, Claudia ; Gabriel, Ludovica ; Rosa Gasco, Maria

Amsterdam: Elsevier B.V

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