Idioma:

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD + in healthy middle-aged and older adults

Martens, Christopher R ; Denman, Blair A ; Mazzo, Melissa R ; Armstrong, Michael L ; Reisdorph, Nichole ; McQueen, Matthew B ; Chonchol, Michel ; Seals, Douglas R

Nature communications, 2018-03, Vol.9 (1), p.1286-11, Article 1286 [Periódico revisado por pares]

England: Nature Publishing Group

Texto completo disponível

Citações Citado por

Enviar para

Título:
Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD + in healthy middle-aged and older adults
Autor: Martens, Christopher R ; Denman, Blair A ; Mazzo, Melissa R ; Armstrong, Michael L ; Reisdorph, Nichole ; McQueen, Matthew B ; Chonchol, Michel ; Seals, Douglas R
Assuntos: Adenine ; Adults ; Aged ; Aging ; Bioavailability ; Blood pressure ; Blood Pressure - drug effects ; Caloric Restriction - methods ; Clinical trials ; Double-Blind Method ; Female ; Humans ; Male ; Medical research ; Metabolism ; Middle age ; Middle Aged ; NAD ; NAD - analysis ; NAD - metabolism ; Niacinamide - analogs & derivatives ; Niacinamide - therapeutic use ; Nicotinamide ; Nicotinamide adenine dinucleotide ; Nutrient deficiency ; Older people ; Physiological effects ; Physiology ; Precursors ; Pyridinium Compounds ; Stiffness ; Substrates ; Supplements ; Vascular Stiffness - drug effects
É parte de: Nature communications, 2018-03, Vol.9 (1), p.1286-11, Article 1286
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Undefined-3
Descrição: Nicotinamide adenine dinucleotide (NAD ) has emerged as a critical co-substrate for enzymes involved in the beneficial effects of regular calorie restriction on healthspan. As such, the use of NAD precursors to augment NAD bioavailability has been proposed as a strategy for improving cardiovascular and other physiological functions with aging in humans. Here we provide the evidence in a 2 × 6-week randomized, double-blind, placebo-controlled, crossover clinical trial that chronic supplementation with the NAD precursor vitamin, nicotinamide riboside (NR), is well tolerated and effectively stimulates NAD metabolism in healthy middle-aged and older adults. Our results also provide initial insight into the effects of chronic NR supplementation on physiological function in humans, and suggest that, in particular, future clinical trials should further assess the potential benefits of NR for reducing blood pressure and arterial stiffness in this group.
Editor: England: Nature Publishing Group
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD + in healthy middle-aged and older adults

Martens, Christopher R ; Denman, Blair A ; Mazzo, Melissa R ; Armstrong, Michael L ; Reisdorph, Nichole ; McQueen, Matthew B ; Chonchol, Michel ; Seals, Douglas R

England: Nature Publishing Group

Buscando em bases de dados remotas. Favor aguardar.