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Factors associated with the development of cardiac allograft vasculopathy - a systematic review of observational studies

Braga, J. R. ; Santos, I. S. O. ; McDonald, M. ; Shah, P. S. ; Ross, H. J.

Clinical transplantation, 2012-03, Vol.26 (2), p.E111-E124 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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  • Título:
    Factors associated with the development of cardiac allograft vasculopathy - a systematic review of observational studies
  • Autor: Braga, J. R. ; Santos, I. S. O. ; McDonald, M. ; Shah, P. S. ; Ross, H. J.
  • Assuntos: cardiac allograft vasculopathy ; Coronary Angiography ; Coronary Disease - diagnostic imaging ; Coronary Disease - etiology ; heart transplantation ; Heart Transplantation - adverse effects ; Humans ; Risk Factors ; systematic review
  • É parte de: Clinical transplantation, 2012-03, Vol.26 (2), p.E111-E124
  • Notas: ArticleID:CTR1565
    istex:67B8F7FCA30A9AFC57B3C7A331D91C987AC5F912
    ark:/67375/WNG-FPVGSBW1-N
    Conflict of interest: the authors of this manuscript have no conflicts of interest to disclose.
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    ObjectType-Feature-4
    ObjectType-Undefined-1
    content type line 23
    ObjectType-Review-2
    ObjectType-Article-3
  • Descrição: Braga JR, Santos ISO, McDonald M, Shah PS, Ross HJ. Factors associated with the development of cardiac allograft vasculopathy – a systematic review of observational studies. 
Clin Transplant 2011 DOI: 10.1111/j.1399‐0012.2011.01565.x. 
© 2011 John Wiley & Sons A/S. :  Cardiac allograft vasculopathy (CAV) is a significant factor impacting outcomes after heart transplant. We performed a systematic review of risk factors for the development of CAV. A search of electronic databases was performed. The eligibility criteria included cohort and case–control studies with more than 50 adult patients submitted to a heart transplant. The outcome should be CAV diagnosed by angiography and/or intravascular ultrasound (IVUS). Two reviewers performed study selection, data ion, and quality assessment. Of 2514 citations, 66 articles were included – 46 had 200 participants or less; 61 were single‐center; and 44 were retrospective cohorts. The most used definition of CAV using angiography was the detection of any degree of abnormality (21 studies of 58). In studies using IVUS, an intimal thickness ≥0.5 mm was the most used definition (five of eight studies). Quality assessment revealed an inadequate description of patient selection, attrition, and accounting of potential confounders. Donor age, recipient age, recipient gender, etiology of heart failure, ischemic time, human leukocyte antigen matching, cytomegalovirus, lipid profile, and rejection episodes were the most studied factors. Our review indicates that the current evidence is not consistent across different studies. The definite contribution of risk factors for the development of CAV is still to be determined.
  • Editor: Oxford, UK: Blackwell Publishing Ltd
  • Idioma: Inglês

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