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Morinda citrifolia Linn (Noni): In vivo and in vitro reproductive toxicology

Müller, Juliane C. ; Botelho, Giuliana G.K. ; Bufalo, Aedra C. ; Boareto, Ana C. ; Rattmann, Yanna D. ; Martins, Elisangela S. ; Cabrini, Daniela A. ; Otuki, Michel F. ; Dalsenter, Paulo R.

Journal of ethnopharmacology, 2009-01, Vol.121 (2), p.229-233 [Periódico revisado por pares]

Shannon: Elsevier Ireland Ltd

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Título:
Morinda citrifolia Linn (Noni): In vivo and in vitro reproductive toxicology
Autor: Müller, Juliane C. ; Botelho, Giuliana G.K. ; Bufalo, Aedra C. ; Boareto, Ana C. ; Rattmann, Yanna D. ; Martins, Elisangela S. ; Cabrini, Daniela A. ; Otuki, Michel F. ; Dalsenter, Paulo R.
Assuntos: animal reproduction ; Animals ; Antiestrogenic activity ; aqueous solutions ; Arachidonic Acid ; Biological and medical sciences ; dose response ; Dose-Response Relationship, Drug ; Estrogen Antagonists - administration & dosage ; Estrogen Antagonists - toxicity ; estrogenic properties ; Female ; Fruit ; General pharmacology ; in vitro studies ; in vivo studies ; Lactation - drug effects ; Lactation - metabolism ; Medical sciences ; medicinal plants ; Morinda - chemistry ; Morinda citrifolia ; Morinda citrifolia Linn ; parturition ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; plant extracts ; Plant Extracts - administration & dosage ; Plant Extracts - toxicity ; Pregnancy ; Rats ; Rats, Wistar ; Reproductive toxicology ; Rubiaceae ; toxicity testing ; Toxicity Tests ; Uterine Contraction - drug effects ; uterus ; Uterus - drug effects ; Uterus - metabolism
É parte de: Journal of ethnopharmacology, 2009-01, Vol.121 (2), p.229-233
Notas: http://dx.doi.org/10.1016/j.jep.2008.10.019
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Descrição: Morinda citrifolia Linn (syn. Noni) is a plant widely used as food and medicine worldwide but there are no toxicological tests about this plant focused on reproduction. To investigate possible endocrine activity and toxic effect on the reproductive system of Wistar rats by exposure of aqueous extract of the Morinda citrifolia. Two experimental protocols in vivo were developed, (a) uterotrophic assay and (b) in utero and lactational assay, and one test in vitro to investigate the effect on the contractility of pregnant uteri isolated from rats (doses of the extract: 7.5, 75 and 750 mg/kg). The uterotrophic assay indicates presence of in vivo antiestrogenic activity of extract at doses of 7.5 and 750 mg/kg. The in utero and lactation exposure showed that the treatment with extract at the dose of 7.5 mg/kg induced a reduction of 50% in parturition index and an increase of 74% in postimplantation losses index. The in vitro test showed that uteri from rats treated with 7.5 mg/kg of the extract presented a 50% reduction on contraction induced by arachidonic acid. The exposure of aqueous extract of Morinda citrifolia in Wistar rats induced reproductive toxicity in nonlinear dose–response.
Editor: Shannon: Elsevier Ireland Ltd
Idioma: Inglês

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Morinda citrifolia Linn (Noni): In vivo and in vitro reproductive toxicology

Müller, Juliane C. ; Botelho, Giuliana G.K. ; Bufalo, Aedra C. ; Boareto, Ana C. ; Rattmann, Yanna D. ; Martins, Elisangela S. ; Cabrini, Daniela A. ; Otuki, Michel F. ; Dalsenter, Paulo R.

Shannon: Elsevier Ireland Ltd

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