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Genomic insights into the Ixodes scapularis tick vector of Lyme disease

Gulia-Nuss, Monika ; Nuss, Andrew B ; Meyer, Jason M ; Sonenshine, Daniel E ; Roe, R Michael ; Waterhouse, Robert M ; Sattelle, David B ; de la Fuente, José ; Ribeiro, Jose M ; Megy, Karine ; Thimmapuram, Jyothi ; Miller, Jason R ; Walenz, Brian P ; Koren, Sergey ; Hostetler, Jessica B ; Thiagarajan, Mathangi ; Joardar, Vinita S ; Hannick, Linda I ; Bidwell, Shelby ; Hammond, Martin P ; Young, Sarah ; Zeng, Qiandong ; Abrudan, Jenica L ; Almeida, Francisca C ; Ayllón, Nieves ; Bhide, Ketaki ; Bissinger, Brooke W ; Bonzon-Kulichenko, Elena ; Buckingham, Steven D ; Caffrey, Daniel R ; Caimano, Melissa J ; Croset, Vincent ; Driscoll, Timothy ; Gilbert, Don ; Gillespie, Joseph J ; Giraldo-Calderón, Gloria I ; Grabowski, Jeffrey M ; Jiang, David ; Khalil, Sayed M S ; Kim, Donghun ; Kocan, Katherine M ; Koči, Juraj ; Kuhn, Richard J ; Kurtti, Timothy J ; Lees, Kristin ; Lang, Emma G ; Kennedy, Ryan C ; Kwon, Hyeogsun ; Perera, Rushika ; Qi, Yumin ; Radolf, Justin D ; Sakamoto, Joyce M ; Sánchez-Gracia, Alejandro ; Severo, Maiara S ; Silverman, Neal ; Šimo, Ladislav ; Tojo, Marta ; Tornador, Cristian ; Van Zee, Janice P ; Vázquez, Jesús ; Vieira, Filipe G ; Villar, Margarita ; Wespiser, Adam R ; Yang, Yunlong ; Zhu, Jiwei ; Arensburger, Peter ; Pietrantonio, Patricia V ; Barker, Stephen C ; Shao, Renfu ; Zdobnov, Evgeny M ; Hauser, Frank ; Grimmelikhuijzen, Cornelis J P ; Park, Yoonseong ; Rozas, Julio ; Benton, Richard ; Pedra, Joao H F ; Nelson, David R ; Unger, Maria F ; Tubio, Jose M C ; Tu, Zhijian ; Robertson, Hugh M ; Shumway, Martin ; Sutton, Granger ; Wortman, Jennifer R ; Lawson, Daniel ; Wikel, Stephen K ; Nene, Vishvanath M ; Fraser, Claire M ; Collins, Frank H ; Birren, Bruce ; Nelson, Karen E ; Caler, Elisabet ; Hill, Catherine A

Nature communications, 2016-02, Vol.7, p.10507 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Genomic insights into the Ixodes scapularis tick vector of Lyme disease
Autor: Gulia-Nuss, Monika ; Nuss, Andrew B ; Meyer, Jason M ; Sonenshine, Daniel E ; Roe, R Michael ; Waterhouse, Robert M ; Sattelle, David B ; de la Fuente, José ; Ribeiro, Jose M ; Megy, Karine ; Thimmapuram, Jyothi ; Miller, Jason R ; Walenz, Brian P ; Koren, Sergey ; Hostetler, Jessica B ; Thiagarajan, Mathangi ; Joardar, Vinita S ; Hannick, Linda I ; Bidwell, Shelby ; Hammond, Martin P ; Young, Sarah ; Zeng, Qiandong ; Abrudan, Jenica L ; Almeida, Francisca C ; Ayllón, Nieves ; Bhide, Ketaki ; Bissinger, Brooke W ; Bonzon-Kulichenko, Elena ; Buckingham, Steven D ; Caffrey, Daniel R ; Caimano, Melissa J ; Croset, Vincent ; Driscoll, Timothy ; Gilbert, Don ; Gillespie, Joseph J ; Giraldo-Calderón, Gloria I ; Grabowski, Jeffrey M ; Jiang, David ; Khalil, Sayed M S ; Kim, Donghun ; Kocan, Katherine M ; Koči, Juraj ; Kuhn, Richard J ; Kurtti, Timothy J ; Lees, Kristin ; Lang, Emma G ; Kennedy, Ryan C ; Kwon, Hyeogsun ; Perera, Rushika ; Qi, Yumin ; Radolf, Justin D ; Sakamoto, Joyce M ; Sánchez-Gracia, Alejandro ; Severo, Maiara S ; Silverman, Neal ; Šimo, Ladislav ; Tojo, Marta ; Tornador, Cristian ; Van Zee, Janice P ; Vázquez, Jesús ; Vieira, Filipe G ; Villar, Margarita ; Wespiser, Adam R ; Yang, Yunlong ; Zhu, Jiwei ; Arensburger, Peter ; Pietrantonio, Patricia V ; Barker, Stephen C ; Shao, Renfu ; Zdobnov, Evgeny M ; Hauser, Frank ; Grimmelikhuijzen, Cornelis J P ; Park, Yoonseong ; Rozas, Julio ; Benton, Richard ; Pedra, Joao H F ; Nelson, David R ; Unger, Maria F ; Tubio, Jose M C ; Tu, Zhijian ; Robertson, Hugh M ; Shumway, Martin ; Sutton, Granger ; Wortman, Jennifer R ; Lawson, Daniel ; Wikel, Stephen K ; Nene, Vishvanath M ; Fraser, Claire M ; Collins, Frank H ; Birren, Bruce ; Nelson, Karen E ; Caler, Elisabet ; Hill, Catherine A
Assuntos: Anaplasma phagocytophilum ; Animals ; Arachnid Vectors - genetics ; Gene Expression Profiling ; Genome - genetics ; Genomics ; Ixodes - genetics ; Ligand-Gated Ion Channels - genetics ; Lyme Disease - transmission ; Oocytes ; Xenopus laevis
É parte de: Nature communications, 2016-02, Vol.7, p.10507
Notas: Present address: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Present address: Department of Microbiology, Immunology, and Pathology, Arthropod-borne & Infectious Diseases Laboratory, Colorado State University, Fort Collins, Colorado 80523, USA
Present address: Department of Haematology, University of Cambridge, NHSBT Building, Long Road, Cambridge CB2 0PT, UK
Present address: French National Institute of Agricultural Research, UMR-BIPAR INRA-ANSES-ENVA, Maisons-Alfort, 94700 France
Present address: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119074
Present address: Department of Biotechnology, Monsanto Company, Chesterfield, Missouri 63017, USA
Present address: Genome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Present address: International Livestock Research Institute, Nairobi 00100, Kenya
These authors contributed equally to this work
Present address: Centre for Neural Circuits and Behaviour, University of Oxford, Oxford OX1 3SR, UK
Present address: Seres Therapeutics, Cambridge, MA 02142, USA
Present address: National Heart, Lung, and Blood Institute, Division of Lung Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Present address: Department of Biochemistry and Molecular Biology, University of Nevada, Reno, Nevada 89503, USA
Deceased.
Present address: Department of Entomology, Iowa State University, Ames, Iowa 50011, USA
Present address: Department of Biology, West Virginia University, Morgantown 26505, West Virginia
Present address: Rocky Mountain Laboratories, Biology of Vector-Borne Viruses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
Present address: Department of Veterinary Medicine, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
Present address: Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA
Present address: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
Present address: Department of Entomology, Kansas State University, Manhattan, Kansas 66506, USA
Present address: Department of Agriculture, Nutrition, and Veterinary Science, University of Nevada, Reno, Nevada 89557, USA
Present address: Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Present address: Department of Vector Biology, Max-Planck-Institut für Infektionsbiologie, Charitéplatz 1, 10117 Berlin, Germany
Present address: AgBiome, Inc., Research Triangle Park, North Carolina 27709, USA
Present address: Nevada Institute of Personalized Medicine, University of Nevada, Las Vegas, Nevada, 89154, USA
Descrição: Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. The large genome reflects accumulation of repetitive DNA, new lineages of retro-transposons, and gene architecture patterns resembling ancient metazoans rather than pancrustaceans. Annotation of scaffolds representing ∼57% of the genome, reveals 20,486 protein-coding genes and expansions of gene families associated with tick-host interactions. We report insights from genome analyses into parasitic processes unique to ticks, including host 'questing', prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival. We identify proteins associated with the agent of human granulocytic anaplasmosis, an emerging disease, and the encephalitis-causing Langat virus, and a population structure correlated to life-history traits and transmission of the Lyme disease agent.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Genomic insights into the Ixodes scapularis tick vector of Lyme disease

England: Nature Publishing Group

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