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Human protein-coding genes and gene feature statistics in 2019

Piovesan, Allison ; Antonaros, Francesca ; Vitale, Lorenza ; Strippoli, Pierluigi ; Pelleri, Maria Chiara ; Caracausi, Maria

BMC research notes, 2019-06, Vol.12 (1), p.315-315, Article 315 [Periódico revisado por pares]

England: BioMed Central Ltd

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Título:
Human protein-coding genes and gene feature statistics in 2019
Autor: Piovesan, Allison ; Antonaros, Francesca ; Vitale, Lorenza ; Strippoli, Pierluigi ; Pelleri, Maria Chiara ; Caracausi, Maria
Assuntos: Analysis ; Annotations ; Biotechnology ; Chromosomes ; Datasets ; DNA sequencing ; Down syndrome ; Exons ; Gene expression ; Gene statistics ; Genes ; Genetic research ; Genomes ; Genomics ; Human genes ; Human genome ; Introns ; Isoforms ; Nucleotide sequencing ; Protein-coding genes ; Proteins ; Research Note ; Ribonucleic acid ; RNA ; Software upgrading ; Spreadsheet software ; Statistical analysis ; Technology application ; Web browsers
É parte de: BMC research notes, 2019-06, Vol.12 (1), p.315-315, Article 315
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: A well-known limit of genome browsers is that the large amount of genome and gene data is not organized in the form of a searchable database, hampering full management of numerical data and free calculations. Due to the continuous increase of data deposited in genomic repositories, their content revision and analysis is recommended. Using GeneBase, a software with a graphical interface able to import and elaborate National Center for Biotechnology Information (NCBI) Gene database entries, we provide tabulated spreadsheets updated to 2019 about human nuclear protein-coding gene data set ready to be used for any type of analysis about genes, transcripts and gene organization. Comparison with previous reports reveals substantial change in the number of known nuclear protein-coding genes (now 19,116), the protein-coding non-redundant transcriptome space [now 59,281,518 base pair (bp), 10.1% increase], the number of exons (now 562,164, 36.2% increase) due to a relevant increase of the RNA isoforms recorded. Other parameters such as gene, exon or intron mean and extreme length appear to have reached a stability that is unlikely to be substantially modified by human genome data updates, at least regarding protein-coding genes. Finally, we confirm that there are no human introns shorter than 30 bp.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Human protein-coding genes and gene feature statistics in 2019

Piovesan, Allison ; Antonaros, Francesca ; Vitale, Lorenza ; Strippoli, Pierluigi ; Pelleri, Maria Chiara ; Caracausi, Maria

England: BioMed Central Ltd

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