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JAK signaling globally counteracts heterochromatic gene silencing

Li, Willis X ; Shi, Song ; Calhoun, Healani C ; Xia, Fan ; Li, Jinghong ; Le, Long

Nature genetics, 2006-09, Vol.38 (9), p.1071-1076 [Periódico revisado por pares]

London: Nature Publishing Group

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Título:
JAK signaling globally counteracts heterochromatic gene silencing
Autor: Li, Willis X ; Shi, Song ; Calhoun, Healani C ; Xia, Fan ; Li, Jinghong ; Le, Long
Assuntos: Animals ; beta-Galactosidase - analysis ; beta-Galactosidase - metabolism ; Biological and medical sciences ; Cellular signal transduction ; Drosophila - genetics ; Drosophila - metabolism ; Drosophila melanogaster ; Drosophila Proteins - genetics ; Drosophila Proteins - metabolism ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Silencing ; Genetic aspects ; Genetic transcription ; Genetics ; Genetics of eukaryotes. Biological and molecular evolution ; Heterochromatin - genetics ; Immunohistochemistry ; Insects ; Janus Kinases ; Mutation ; Oncology ; Physiological aspects ; Protein-Tyrosine Kinases - genetics ; Protein-Tyrosine Kinases - metabolism ; Signal Transduction ; STAT Transcription Factors - genetics ; STAT Transcription Factors - metabolism ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Tumors
É parte de: Nature genetics, 2006-09, Vol.38 (9), p.1071-1076
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Descrição: The JAK/STAT pathway has pleiotropic roles in animal development, and its aberrant activation is implicated in multiple human cancers. JAK/STAT signaling effects have been attributed largely to direct transcriptional regulation by STAT of specific target genes that promote tumor cell proliferation or survival. We show here in a Drosophila melanogaster hematopoietic tumor model, however, that JAK overactivation globally disrupts heterochromatic gene silencing, an epigenetic tumor suppressive mechanism. This disruption allows derepression of genes that are not direct targets of STAT, as evidenced by suppression of heterochromatin-mediated position effect variegation. Moreover, mutations in the genes encoding heterochromatin components heterochromatin protein 1 (HP1) and Su(var)3-9 enhance tumorigenesis induced by an oncogenic JAK kinase without affecting JAK/STAT signaling. Consistently, JAK loss of function enhances heterochromatic gene silencing, whereas overexpressing HP1 suppresses oncogenic JAK-induced tumors. These results demonstrate that the JAK/STAT pathway regulates cellular epigenetic status and that globally disrupting heterochromatin-mediated tumor suppression is essential for tumorigenesis induced by JAK overactivation.
Editor: London: Nature Publishing Group
Idioma: Inglês

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JAK signaling globally counteracts heterochromatic gene silencing

Li, Willis X ; Shi, Song ; Calhoun, Healani C ; Xia, Fan ; Li, Jinghong ; Le, Long

London: Nature Publishing Group

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