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HOMOLOGOUS RECOMBINATION NEAR AND FAR FROM DNA BREAKS: Alternative Roles and Contrasting Views

Smith, Gerald R

Annual review of genetics, 2001-01, Vol.35 (1), p.243-274 [Periódico revisado por pares]

Palo Alto, CA 94303-0139: Annual Reviews

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Título:
HOMOLOGOUS RECOMBINATION NEAR AND FAR FROM DNA BREAKS: Alternative Roles and Contrasting Views
Autor: Smith, Gerald R
Assuntos: Analysis ; Animals ; Bacteria ; Chi ; Chromosome replication ; Deoxyribonucleic acid ; DNA ; DNA - metabolism ; DNA Repair - physiology ; DNA replication ; DNA Replication - genetics ; DNA-Binding Proteins - genetics ; enzyme induction ; Enzymes ; Escherichia coli ; Escherichia coli - genetics ; Exodeoxyribonuclease V ; Exodeoxyribonucleases - genetics ; Fungal Proteins - genetics ; Fungi ; Genetic aspects ; Genetic recombination ; Genetic research ; heteroduplex DNA ; Meiosis ; Models, Genetic ; RecB protein ; RecBCD enzyme ; RecC protein ; RecD protein ; recombination hotspots ; Recombination, Genetic - physiology
É parte de: Annual review of genetics, 2001-01, Vol.35 (1), p.243-274
Notas: ObjectType-Article-2
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Descrição: Double-strand breaks and other lesions in DNA can stimulate homologous genetic recombination in two quite different ways: by promoting recombination near the break (roughly within a kb) or far from the break. Recent emphasis on the repair aspect of recombination has focused attention on DNA interactions and recombination near breaks. Here I review evidence for recombination far from DNA breaks in bacteria and fungi and discuss mechanisms by which this can occur. These mechanisms include entry of a traveling entity ("recombination machine") at a break, formation of long heteroduplex DNA, priming of DNA replication by a broken end, and induction of recombination potential in trans . Special emphasis is placed on contrasting views of how the RecBCD enzyme of Escherichia coli promotes recombination far (tens of kb) from a double-strand break. The occurrence of recombination far from DNA breaks and of correlated recombination events far apart suggests that "action at a distance" during recombination is a widespread feature among diverse organisms.
Editor: Palo Alto, CA 94303-0139: Annual Reviews
Idioma: Inglês

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HOMOLOGOUS RECOMBINATION NEAR AND FAR FROM DNA BREAKS: Alternative Roles and Contrasting Views

Smith, Gerald R

Palo Alto, CA 94303-0139: Annual Reviews

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