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Endothelial fluid shear stress sensing in vascular health and disease

Baeyens, Nicolas ; Bandyopadhyay, Chirosree ; Coon, Brian G ; Yun, Sanguk ; Schwartz, Martin A

The Journal of clinical investigation, 2016-03, Vol.126 (3), p.821-828 [Periódico revisado por pares]

United States: American Society for Clinical Investigation

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Título:
Endothelial fluid shear stress sensing in vascular health and disease
Autor: Baeyens, Nicolas ; Bandyopadhyay, Chirosree ; Coon, Brian G ; Yun, Sanguk ; Schwartz, Martin A
Assuntos: Animals ; Atherosclerosis ; Atherosclerosis - physiopathology ; Biomechanical Phenomena ; Biomedical research ; Blood pressure ; Cellular signal transduction ; Disease ; Disease susceptibility ; Endothelium, Vascular - physiopathology ; Gene expression ; Health aspects ; Humans ; Kinases ; Mechanotransduction, Cellular ; Medical research ; Medicine, Experimental ; Morphogenesis ; Mutation ; Physiology ; Plaque, Atherosclerotic - physiopathology ; Proteins ; Review ; Shear stress ; Transcription factors ; Vascular Remodeling
É parte de: The Journal of clinical investigation, 2016-03, Vol.126 (3), p.821-828
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
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Authorship note: N. Baeyens, C. Bandyopadhyay, B.G. Coon, and S. Yun contributed equally to this work and are listed in alphabetical order.
Descrição: Endothelial cells transduce the frictional force from blood flow (fluid shear stress) into biochemical signals that regulate gene expression and cell behavior via specialized mechanisms and pathways. These pathways shape the vascular system during development and during postnatal and adult life to optimize flow to tissues. The same pathways also contribute to atherosclerosis and vascular malformations. This Review covers recent advances in basic mechanisms of flow signaling and the involvement of these mechanisms in vascular physiology, remodeling, and these diseases. We propose that flow sensing pathways that govern normal morphogenesis can contribute to disease under pathological conditions or can be altered to induce disease. Viewing atherosclerosis and vascular malformations as instances of pathological morphogenesis provides a unifying perspective that may aid in developing new therapies.
Editor: United States: American Society for Clinical Investigation
Idioma: Inglês

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Endothelial fluid shear stress sensing in vascular health and disease

Baeyens, Nicolas ; Bandyopadhyay, Chirosree ; Coon, Brian G ; Yun, Sanguk ; Schwartz, Martin A

United States: American Society for Clinical Investigation

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