Idioma:

Changes in pentobarbital induced sleeping-time in mice infected with Schistosoma mansoni and immunosuppressed

Tonelli, S M ; Brasileiro Filho, G ; Goulart, E M ; Coelho, P M

Revista do Instituto de Medicina Tropical de São Paulo, 1995-04, Vol.37 (2), p.149-153 [Periódico revisado por pares]

Brazil: Instituto de Medicina Tropical

Texto completo disponível

Citações Citado por

Enviar para

Título:
Changes in pentobarbital induced sleeping-time in mice infected with Schistosoma mansoni and immunosuppressed
Autor: Tonelli, S M ; Brasileiro Filho, G ; Goulart, E M ; Coelho, P M
Assuntos: Animals ; Azathioprine - therapeutic use ; Female ; Hypnotics and Sedatives - pharmacology ; Immunosuppression ; Immunosuppressive Agents - therapeutic use ; Liver - metabolism ; Liver - pathology ; Mice ; Mice, Inbred BALB C ; Pentobarbital - pharmacology ; Schistosomiasis mansoni - drug therapy ; Schistosomiasis mansoni - physiopathology ; Schistosomiasis mansoni - radiotherapy ; Sleep - physiology ; Time Factors ; TROPICAL MEDICINE
É parte de: Revista do Instituto de Medicina Tropical de São Paulo, 1995-04, Vol.37 (2), p.149-153
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: To evaluate whether the intensity of the hepatic granulomatous response induced by S. mansoni eggs plays a role in drug metabolism, mice were infected with 40 cercariae and tested to assess the sodic pentobarbital induced sleeping-time. To decrease the inflammatory reaction the animals were irradiated with 400 Rad or received azathioprine, 20 mg/kg, 3 times a week, for 4 weeks, respectively in or beginning in the 33th post-infection day. In infected animals receiving azathioprine the area of the hepatic granulomas was smaller and the sleeping-time was similar to that of non-infected ones (controls). In mice infected and irradiated the granuloma dimensions were similar to those of animals only infected, in these two latter groups of animals, the sleeping-time was more prolonged than that of the control animals. These results show that: 1) mice with unaltered hepatic granulomatous reaction show reduction in metabolism of sodic pentobarbital; 2) granulomatous response diminished by azathioprine does not interfere with the capacity of metabolism of the anesthetic drug.
Editor: Brazil: Instituto de Medicina Tropical
Idioma: Inglês;Português

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Changes in pentobarbital induced sleeping-time in mice infected with Schistosoma mansoni and immunosuppressed

Tonelli, S M ; Brasileiro Filho, G ; Goulart, E M ; Coelho, P M

Brazil: Instituto de Medicina Tropical

Buscando em bases de dados remotas. Favor aguardar.