Idioma:

Frequency of Interleukin-4 (IL-4) -589 Gene Polymorphism and Vaginal Concentrations of IL-4, Nitric Oxide, and Mannose-Binding Lectin in Women with Recurrent Vulvovaginal Candidiasis

Babula, Oksana ; Lazdāne, Gunta ; Kroica, Juta ; Linhares, Iara M. ; Ledger, William J. ; Witkin, Steven S.

Clinical infectious diseases, 2005-05, Vol.40 (9), p.1258-1262 [Periódico revisado por pares]

Chicago, IL: The University of Chicago Press

Texto completo disponível

Citações Citado por

Enviar para

Título:
Frequency of Interleukin-4 (IL-4) -589 Gene Polymorphism and Vaginal Concentrations of IL-4, Nitric Oxide, and Mannose-Binding Lectin in Women with Recurrent Vulvovaginal Candidiasis
Autor: Babula, Oksana ; Lazdāne, Gunta ; Kroica, Juta ; Linhares, Iara M. ; Ledger, William J. ; Witkin, Steven S.
Assuntos: Adolescent ; Adult ; Alleles ; Biological and medical sciences ; Candida ; Candida albicans ; Candida krusei ; Candida tropicalis ; Candidiasis ; Candidiasis, Vulvovaginal - genetics ; Female ; Genes ; Genetic Predisposition to Disease ; Genotype ; Genotypes ; Homozygote ; Human mycoses ; Humans ; Infections ; Infectious diseases ; Interleukin-4 - genetics ; Interleukin-4 - metabolism ; Lectins ; Macrophages ; Major Articles ; Mannose-Binding Lectin - metabolism ; Medical diagnosis ; Medical sciences ; Mycoses ; Mycoses of the genital system ; Nitric Oxide - metabolism ; Oxides ; Polymorphism ; Polymorphism, Single Nucleotide - genetics ; Reproductive system ; T lymphocytes ; Vagina - metabolism ; Vulvovaginal candidiasis ; Women
É parte de: Clinical infectious diseases, 2005-05, Vol.40 (9), p.1258-1262
Notas: ark:/67375/HXZ-6D5CL2GC-M
istex:5884CF790EBD5070EC1591B877A7F1407BD955E1
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
Descrição: Background. A C→T substitution at position -589 in the interleukin-4 (IL-4) gene is associated with increased production of IL-4. Associations between this polymorphism and recurrent vulvovaginal candidiasis (RVVC), as well as vaginal concentrations of IL-4 and the anticandidal compounds nitric oxide (NO) and mannose binding lectin (MBL), were evaluated. Methods. Vaginal samples obtained by lavage from 42 women with RVVC during the acute stage of the disease and 43 control samples were assayed by enzyme-linked immunosorbent assay for IL-4 and NO metabolites. The -589 IL-4 gene polymorphism was detected by polymerase chain reaction and endonuclease digestion. Data were analyzed by Fisher's exact test, the nonparametric Mann-Whitney and Kruskal-Wallis tests, and Spearman rank correlation. P < .05 was considered significant. Results. Candida albicans was identified in 38 patients with RVVC; 3 others had infection due to Candida tropicalis, and 1 had infection due to Candida krusei. The IL-4 T,T genotype was detected in 59.5% of patients with RVVC and in 7.0% of control subjects (P < .0001). The frequency of IL-4*T was 76.2% in patients with RVVC and 23.3% in control subjects (P < .0001). The median concentration of vaginal IL-4 was elevated in patients with RVVC, compared with control subjects (P < .0001). Conversely, vaginal concentrations of NO metabolites (P = .02) and MBL (P < .0001) were reduced in patients with RVVC. There was a positive association between IL-4*T homozygosity and vaginal IL-4 levels (P < .0001) and negative associations between this genotype and vaginal NO (P = .01) and MBL (P < .0001) concentrations. Conclusions. Reduced vaginal levels of anticandidal factors in IL-4*T homozygotes may increase susceptibility to RVVC.
Editor: Chicago, IL: The University of Chicago Press
Idioma: Inglês

Links

Voltar para lista de resultados

Resultado 1 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Frequency of Interleukin-4 (IL-4) -589 Gene Polymorphism and Vaginal Concentrations of IL-4, Nitric Oxide, and Mannose-Binding Lectin in Women with Recurrent Vulvovaginal Candidiasis

Babula, Oksana ; Lazdāne, Gunta ; Kroica, Juta ; Linhares, Iara M. ; Ledger, William J. ; Witkin, Steven S.

Chicago, IL: The University of Chicago Press

Buscando em bases de dados remotas. Favor aguardar.