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Regulation of Trypanosoma cruzi-Induced Myocarditis by Programmed Death Cell Receptor 1

Gutierrez, Fredy R.S ; Mariano, Flávia S ; Oliveira, Carlo J.F ; Pavanelli, Wander R ; Guedes, Paulo M.M ; Silva, Grace K ; Campanelli, Ana P ; Milanezi, Cristiane M ; Azuma, Miyuki ; Honjo, Tasuku ; Teixeira, Mauro M ; Aliberti, Julio C.S ; Silva, João S Urban, J. F.

Infection and Immunity, 2011-05, Vol.79 (5), p.1873-1881 [Periódico revisado por pares]

Washington, DC: American Society for Microbiology

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Título:
Regulation of Trypanosoma cruzi-Induced Myocarditis by Programmed Death Cell Receptor 1
Autor: Gutierrez, Fredy R.S ; Mariano, Flávia S ; Oliveira, Carlo J.F ; Pavanelli, Wander R ; Guedes, Paulo M.M ; Silva, Grace K ; Campanelli, Ana P ; Milanezi, Cristiane M ; Azuma, Miyuki ; Honjo, Tasuku ; Teixeira, Mauro M ; Aliberti, Julio C.S ; Silva, João S
Urban, J. F.
Assuntos: adaptive immunity ; Animals ; antibodies ; antigen-presenting cells ; Antigens, Surface - immunology ; Antigens, Surface - metabolism ; apoptosis ; Apoptosis Regulatory Proteins - immunology ; Apoptosis Regulatory Proteins - metabolism ; Biological and medical sciences ; cardiomyopathy ; Cell Separation ; Chagas Cardiomyopathy - immunology ; Chagas Cardiomyopathy - metabolism ; Chagas disease ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Fluorescent Antibody Technique ; Fundamental and applied biological sciences. Psychology ; Host Response and Inflammation ; immunoglobulin G ; Immunohistochemistry ; inflammation ; Life cycle. Host-agent relationship. Pathogenesis ; lymphocytes ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microbiology ; mortality ; myocarditis ; myocardium ; parasitemia ; parasitism ; pathogenesis ; Programmed Cell Death 1 Receptor ; Protozoa ; rats ; Reverse Transcriptase Polymerase Chain Reaction ; signal transduction ; Signal Transduction - immunology ; T-Lymphocytes - immunology ; Trypanosoma cruzi ; Trypanosoma cruzi - immunology
É parte de: Infection and Immunity, 2011-05, Vol.79 (5), p.1873-1881
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Present address: School of Medicine, University Antonio Nariño, Bogotá, Colombia.
Descrição: Trypanosoma cruzi infection causes intense myocarditis, leading to cardiomyopathy and severe cardiac dysfunction. Protective adaptive immunity depends on balanced signaling through a T cell receptor and coreceptors expressed on the T cell surface. Such coreceptors can trigger stimulatory or inhibitory signals after binding to their ligands in antigen-presenting cells (APC). T. cruzi modulates the expression of coreceptors in lymphocytes after infection. Deregulated inflammation may be due to unbalanced expression of these molecules. Programmed death cell receptor 1 (PD-1) is a negative T cell coreceptor that has been associated with T cell anergy or exhaustion and persistent intracellular infections. We aimed to study the role of PD-1 during T. cruzi-induced acute myocarditis in mice. Cytometry assays showed that PD-1 and its ligands are strongly upregulated in lymphocytes and APC in response to T. cruzi infection in vivo and in vitro. Lymphocytes infiltrating the myocardium exhibited high levels of expression of these molecules. An increased cardiac inflammatory response was found in mice treated with blocking antibodies against PD-1, PD-L1, and to a lesser extent, PD-L2, compared to that found in mice treated with rat IgG. Similar results in PD-1⁻/⁻ mice were obtained. Moreover, the PD-1 blockade/deficiency led to reduced parasitemia and tissue parasitism but increased mortality. These results suggest the participation of a PD-1 signaling pathway in the control of acute myocarditis induced by T. cruzi and provide additional insight into the regulatory mechanisms in the pathogenesis of Chagas' disease.
Editor: Washington, DC: American Society for Microbiology
Idioma: Inglês

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Regulation of Trypanosoma cruzi-Induced Myocarditis by Programmed Death Cell Receptor 1

Gutierrez, Fredy R.S ; Mariano, Flávia S ; Oliveira, Carlo J.F ; Pavanelli, Wander R ; Guedes, Paulo M.M ; Silva, Grace K ; Campanelli, Ana P ; Milanezi, Cristiane M ; Azuma, Miyuki ; Honjo, Tasuku ; Teixeira, Mauro M ; Aliberti, Julio C.S ; Silva, João S Urban, J. F.

Washington, DC: American Society for Microbiology

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