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Tuberculosis in renal transplant patients; Tuberculose em pacientes transplantados renais

Paula, Flávio Jota De; Azevedo, Luiz Sérgio; Saldanha, Luiz Balthazar; Ianhez, Luiz Estevam; Sabbaga, Emil

Revista do Instituto de Medicina Tropical de São Paulo; Vol. 29 No. 5 (1987); 268-275

Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo 1987-10-01

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  • Título:
    Tuberculosis in renal transplant patients; Tuberculose em pacientes transplantados renais
  • Autor: Paula, Flávio Jota De; Azevedo, Luiz Sérgio; Saldanha, Luiz Balthazar; Ianhez, Luiz Estevam; Sabbaga, Emil
  • Assuntos: Tuberculosis; Kidney Transplantation; Infection; Immunosuppression
  • É parte de: Revista do Instituto de Medicina Tropical de São Paulo; Vol. 29 No. 5 (1987); 268-275
  • Descrição: Tuberculosis (TB) was diagnosed in 25 of 466 patients who underwent renal transplant over a period of 15 years. TB developed from 1 month to 9 years post-transplant. In 56% of the cases the onset was within the first post-transplant year. TB affected several isolated or combined organs. Pulmonary involvement was present in 76% of cases, either as isolated pleuro-pulmonary (56%) or associated with other sites (20%). The non-pulmonary sites were: skin, joints, tests, urinary tract, central nervous system and lymphonodules. The diagnosis was confirmed by biopsy in 64% of the cases, by identification of tubercle bacilli in 24% and only at necropsy in 12% Biopsy specimens could be classified in three histological forms: exudative, that occurred in early onset and more severe cases granulomatous in late onset and benign cases; and mixed in intermediate cases. Azathioprine dosages were similar along post-transplant time periods in TB patients and in the control groups; and in TB patients who were cured and who died. The number of steroid treated rejection crises was greater in TB than in the control group. Prednisone doses were higher and the number of rejection crises was greater in TB patients who died than in those who were cured. Fifteen patients were cured and ten died, two of them of causes unrelated to TB. Six of the eight TB-related deaths occurred in the first 6 post-transplant months. The outcome was poor in patients in whom TB arose early in post-transplant period and where the exudative or mixed forms were present; whereas the prognosis was good in patients with late onset and granulomatous form of TB. In one patient TB was transmitted by the allograft.
    Tuberculose (TB) foi diagnosticada em 25 de 466 pacientes submetidos a transplante renal. A TB surgiu entre 1 mês e 9 anos pós-transplante. O pulmão foi acometido em 76% dos casos, isoladamente (56%), ou associado a outras localizações (20%). Os outros órgãos envolvidos foram: pele, articulações, testículos, trato urinário, sistema nervoso central e linfonodos. O diagnóstico foi confirmado por biópsia em 64% dos casos, pela identificação do bacilo em 24% e apenas à necrópsia em 12%. Três formas histológicas foram identificadas: exudativa (nos casos de aparecimento precoce e de maior gravidade) granulomatosa (naqueles benignos e de aparecimento tardio) e mista (naqueles intermediários). As doses de azatioprina foram constantes ao longo do período pós-transplante, tanto no grupo tuberculoso como no controle, bem como nos pacientes tuberculosos que faleceram e que se curaram. O número de crises de rejeição tratadas foi maior no grupo TB do que no grupo controle. As doses de prednisona e o número de crises de rejeição foram maiores nos pacientes tuberculosos que faleceram do que naqueles que sobreviveram. Quinze pacientes se curaram e 10 faleceram, oito de causas relacionadas à TB, Seis destes óbitos ocorreram nos 6 primeiros meses pós-transplante. Em um paciente a TB foi transmitida pelo enxerto.
  • Títulos relacionados: https://www.revistas.usp.br/rimtsp/article/view/28530/30383
  • Editor: Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
  • Data de criação/publicação: 1987-10-01
  • Formato: Adobe PDF
  • Idioma: Inglês

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